ArticleInternational journal of methods in psychiatric research2025
The Intergenerational Impact of Maternal Childhood Adversity on Child Behavior and Neurodevelopment: The Healthy MiNDS Protocol.
Article in International journal of methods in psychiatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A Guide to Enzymatic Targeted Methylation Sequencing Bioinformatics Workflow: Best Practices.Current protocols · 2026Article
- Maternal adverse childhood experiences, postnatal depression, and early parenting behaviors: a study of microcoded mother-infant interaction in early infancy.Frontiers in child and adolescent psychiatry · 2026Article
- Mother infant cortisol levels and maternal childhood adversity.Scientific reports · 2025Article
- The Intergenerational Impact of Maternal Childhood Adversity on Child Behavior and Neurodevelopment: The Healthy MiNDS Protocol.International journal of methods in psychiatric research · 2025Article
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Authors and funding
13 authors.
Funding
Abstract
objectivesHere we present Healthy MiNDS, a cohort of mothers and their newborns in São Paulo, Brazil, designed to investigate how maternal adverse childhood experiences (ACEs) intergenerationally affect child behavior and neurodevelopment, while exploring underlying biological mechanisms.
methodsThe study included seven encounters, beginning with the enrollment of women at 25-39 weeks of gestation from a low-resource area, based on their high or low exposure to ACEs. Their newborns were followed through the first 2 years of life. Biospecimens (e.g. maternal and cord blood, hair, saliva, placenta) were collected before/during childbirth and at follow-up visits. Newborns underwent non-sedated brain MRI scans and were regularly assessed for behavior, mother-child interactions, and home environment.
resultsWe enrolled 626 mothers, with 60% of those who provided ACEs information (n = 603) reporting three or more ACEs, and 545 mother-child dyads. We obtained 303 MRI scans and 333 placental samples, among other biospecimens. Enrollment and the 6-month follow-up are complete, while the 14-, 18-, and 24-month visits are ongoing for active dyads.
conclusionThe Healthy MiNDS data allows for testing associations between maternal ACEs, prenatal inflammation and stress, placental biology, and offspring brain-behavior development in a population highly exposed to ACEs.
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