ArticleCell reports2025
Single-nucleus neuronal transcriptional profiling of male C. elegans uncovers regulators of sex-specific and sex-shared behaviors.
Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Proximity Labeling inBio-protocol · 2026Article
- Sexual dimorphism in the nervous system: Three principles from the nematode C.elegans.Current opinion in neurobiology · 2026Review
- The extracellular matrix genebioRxiv : the preprint server for biology · 2026Article
- Efficient pheromone navigation via antagonistic detectors in Caenorhabditis elegans male.Nature communications · 2026Article
- A gene expression atlas of a juvenile nervous system.bioRxiv : the preprint server for biology · 2025Article
- Identity and functions of monoaminergic neurons in the predatory nematodebioRxiv : the preprint server for biology · 2025Article
- Multiple autism genes influence GABA neuron remodeling via distinct developmental trajectories.Genetics · 2025Article
- Molecular profiling of adult C. elegans glia across sexes by single-nuclear RNA-seq.Developmental cell · 2025Article
- Pervasive homeobox gene function in the male-specific nervous system of Caenorhabditis elegans.Development (Cambridge, England) · 2025Article
- Review
- CeSTAAN: An atlas ofmicroPublication biology · 2025Article
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Abstract
Sexual differentiation of the nervous system drives profound neurobiological and behavioral differences between the sexes across various organisms, including Caenorhabditis elegans. Using single-nucleus RNA sequencing, we profiled and compared adult male and hermaphrodite C. elegans neurons, generating an atlas of adult male-specific and sex-shared neurons. We expanded the molecular map of male-specific neurons and identified highly dimorphic expression of G protein-coupled receptors (GPCRs), neuropeptides, and ion channels. Our data demonstrate sex-shared neurons exhibit substantial heterogeneity between the sexes, while sex-specific neurons repurpose conserved molecular pathways to regulate dimorphic behaviors. We show that the PHD neurons display remarkable similarity to sex-shared AWA neurons, suggesting partial repurposing of conserved pathways, and that they and the GPCR SRT-18 may play a role in pheromone sensing. We further demonstrate that the ubiquitously expressed MAPK phosphatase vhp-1 regulates both sex-specific and sex-shared behaviors. Our data provide a rich resource for discovering sex-specific transcriptomic differences and the molecular basis of sex-specific behaviors.
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