Evidence map›Paper›PMID 40682719›Full record

ArticleMolecular neurobiology2025

Golden Oyster Mushroom Extract Ameliorates Oxidative Stress-Induced Cell Death in Neurons and Scopolamine-Induced Cholinergic System Impairment in Mice.

Ho-Sung Ryu, Sanjay, Sung-Keun Choi, Kun-Hee Lee, Sung-Soo Jang, Su-Yeon Yang, Young-Sam Kwon, Sae-Kwang Ku, Hae-Jeung Lee

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Ergothioneine-rich water extracts ofFrontiers in nutrition · 2026
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ho-Sung Ryu *Department of Veterinary Surgery, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.ORCID http://orcid.org/0000-0003-4484-8487
Sanjay *Department of Food and Nutrition, College of BioNano Technology, Gachon University, 1342 Seongnamdaero, Sujeong-Gu, Seongnam-Si, 13120, Gyeonggi-Do, Republic of Korea.ORCID http://orcid.org/0000-0003-4571-515X
Sung-Keun ChoiDAEDONG KOREA GINSENG CO., LTD, Geumsan, Republic of Korea.ORCID http://orcid.org/0009-0006-8425-5036
Kun-Hee LeeDAEDONG KOREA GINSENG CO., LTD, Geumsan, Republic of Korea.ORCID http://orcid.org/0009-0001-1914-1888
Sung-Soo JangDAEDONG KOREA GINSENG CO., LTD, Geumsan, Republic of Korea.ORCID http://orcid.org/0009-0007-0232-5764
Su-Yeon YangSHINWOO CO., LTD, Anyang, Republic of Korea.ORCID http://orcid.org/0009-0006-2647-5567
Young-Sam KwonDepartment of Veterinary Surgery, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea.ORCID http://orcid.org/0000-0002-6489-0327
Sae-Kwang KuDepartment of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan, 38610, Republic of Korea. gucci200@hanmail.net.ORCID http://orcid.org/0000-0003-1269-3804
Hae-Jeung LeeDepartment of Food and Nutrition, College of BioNano Technology, Gachon University, 1342 Seongnamdaero, Sujeong-Gu, Seongnam-Si, 13120, Gyeonggi-Do, Republic of Korea. skysea@gachon.ac.kr.ORCID http://orcid.org/0000-0001-8353-3619

Funding

This research was supported by Korea Institute of Marine Science & Technology Promotion (KIMST) funded by the Ministry of Oceans and Fisheries (RS-2023-00236592)
6 · The paper itself

Abstract

Impaired cholinergic system is an important therapeutic target to develop drugs against Alzheimer's disease (AD), as cholinergic signal transduction is associated with the memory, learning, and behavior of an individual. Acetylcholine (ACh) is an important neurotransmitter and is degraded by an enzyme, acetylcholinesterase (AChE), blocking neuronal signal transmission, which leads to amnesia or memory loss. Oxidative stress (OS) also worsens AD pathology by damaging lipids, proteins and DNA of the neuronal cells, leading to neuronal cell death. Golden oyster mushroom (GOM), an edible mushroom native to the regions of Japan, Korea, Russia, and China, has been reported to possess several bioactivities. However, there is no study reported till date, studying the anti-amnesic properties of GOM. The objectives of this study were to assimilate the in vitro neuroprotective and in vivo anti-amnesic properties of GOM. The GOM at 0.1, 0.5, 1, 5, and 10 mg/ml was nontoxic and was able to prevent H

Indexed as

NeuronsOxidative StressScopolamineAcetylcholineAcetylcholinesteraseAnimalsCell DeathCell LineCholinergic NeuronsHydrogen PeroxideMaleMiceNeuroprotective AgentsAcetylcholineAcetylcholinesteraseHydrogen PeroxideNeuroprotective AgentsScopolamineAlzheimer’s diseaseAmnesiaCholinergic systemGolden oyster mushroomMemory lossNeurodegenerationOxidative stressScopolamine

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.