Evidence map›Paper›PMID 40682711›Full record

ArticleMolecular and cellular biochemistry2025

LINC02266 promotes proliferation and metastasis and inhibits ferroptosis of gastric cancer cells by regulating AKT/ACSL4 pathway.

Xiaoru Liang, Xinyu Niu, Lijie Zhang, Chang Liu, Xiaomin Zhao, Feng Chen, Zhijuan Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaoru Liang *Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, 261053, Shandong, China.
Xinyu Niu *Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, 261053, Shandong, China.
Lijie Zhang *Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, 261053, Shandong, China.
Chang LiuKey Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, 261053, Shandong, China.
Xiaomin ZhaoKey Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, 261053, Shandong, China.
Feng ChenFirst Department of Gastrointestinal Surgery, Weifang Hospital of Traditional Chinese Medicine, Shandong Second Medical University, Weifang, 261041, Shandong, China. 15610279319@163.com.
Zhijuan LinKey Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, 261053, Shandong, China. linzhj@sdsmu.edu.cn.

Funding

the National Natural Science Foundation of China No.32000495the Natural Science Foundation of Shandong Province No. ZR2020MH202the Weifang Science and Technology Development Plan Project No. 2024YX039
6 · The paper itself

Abstract

Ferroptosis is a novel form of cell death characterized by iron-dependent oxidative damage, lipid peroxidation, and the accumulation of reactive oxygen species. There exists a close correlation between ferroptosis and gastric cancer (GC). Recent research has shown that many ferroptosis-related long non-coding RNAs (lncRNAs) affect the occurrence and progression of GC. However, the exact mechanism has not been elucidated. This study showed that a novel lncRNA LINC02266 was upregulated in GC cells and was a key lncRNA associated with GC prognosis and progression. Functional analysis indicated that LINC02266 suppressed ferroptosis and promoted GC cell proliferation, migration, invasion, and tumor growth in vitro and vivo. Mechanistically, we found that LINC02266 inhibited erastin-induced ferroptosis by suppressing ACSL4 levels, which may be related to the AKT pathway. This study indicates that LINC02266 can serve as a diagnostic marker and novel therapeutic target for GC.

Indexed as

Gene Expression Regulation, NeoplasticLong-Chain-Fatty-Acid-CoA LigaseProto-Oncogene Proteins c-aktRNA, Long NoncodingStomach NeoplasmsAnimalsCoenzyme A LigasesFerroptosisHumansMaleMiceMice, NudeNeoplasm MetastasisACSL4 protein, humanAcsl4 protein, mouseCoenzyme A LigasesLong-Chain-Fatty-Acid-CoA LigaseProto-Oncogene Proteins c-aktRNA, Long NoncodingACSL4FerroptosisGastric cancerInvasion and migrationLINC02266

Identifiers

PMID40682711
PMCPMC12572070

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.