Evidence map›Paper›PMID 40682702›Full record

Observational studyAnnals of surgical oncology2025

Incidence and Outcomes of Intraductal Oncocytic Papillary Neoplasm-Derived Pancreatic Cancer Compared with Tubular and Colloid Intraductal Papillary Mucinous Neoplasm-Derived Pancreatic Cancer: An International Multicenter Retrospective Study.

Joseph R Habib, Camila Hidalgo Salinas, Natalie F Berger, Ingmar F Rompen, Brady A Campbell, Benedict Kinny-Köster, Paul C M Andel, D Brock Hewitt, Jörg Kaiser, Adrian T Billeter and 12 more

Abstract readComparative StudyMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Does ductal subtype predict outcomes after resection of IPMN-derived pancreatic cancer? An international multi-center retrospective study.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2026
    Article
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Joseph R HabibDepartment of Surgery, New York University Langone Health, New York, NY, USA.
Camila Hidalgo SalinasDepartment of Surgery, New York University Langone Health, New York, NY, USA.
Natalie F BergerDepartment of Surgery, New York University Langone Health, New York, NY, USA.
Ingmar F RompenDepartment of Surgery, New York University Langone Health, New York, NY, USA.
Brady A CampbellDepartment of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA.
Benedict Kinny-KösterHeidelberg University Hospital, Heidelberg, Germany.
Paul C M AndelDepartment of Surgery, New York University Langone Health, New York, NY, USA.
D Brock HewittDepartment of Surgery, New York University Langone Health, New York, NY, USA.
Jörg KaiserHeidelberg University Hospital, Heidelberg, Germany.
Adrian T BilleterClarunis University Digestive Health Care Center, University of Basel, Basel, Switzerland.
Rafael PereraCentre for Evidence-Based Medicine, Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Oxford, UK.
Katherine MorganDepartment of Surgery, New York University Langone Health, New York, NY, USA.
Lois A DaamenDepartment of Surgery, Regional Academic Cancer Center Utrecht, UMC Utrecht Cancer Center and St. Antonius Hospital Nieuwegein, Utrecht, The Netherlands.
Ammar A JavedDepartment of Surgery, New York University Langone Health, New York, NY, USA.
Beat P Müller-StichClarunis University Digestive Health Care Center, University of Basel, Basel, Switzerland.
Marc G BesselinkDepartment of Surgery, Amsterdam UMC, Location University of Amsterdam, Amsterdam, The Netherlands.
Jin HeDepartment of Surgery, Johns Hopkins Hospital, Baltimore, MD, USA.
I Quintus MolenaarDepartment of Surgery, Regional Academic Cancer Center Utrecht, UMC Utrecht Cancer Center and St. Antonius Hospital Nieuwegein, Utrecht, The Netherlands.
Markus W BüchlerChampalimaud Foundation, Lisbon, Portugal.
Christopher L WolfgangDepartment of Surgery, New York University Langone Health, New York, NY, USA.
Martin LoosHeidelberg University Hospital, Heidelberg, Germany.
Greg D SacksDepartment of Surgery, New York University Langone Health, New York, NY, USA. Greg.sacks@nyulangone.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntraductal papillary mucinous neoplasm (IPMN)-derived pancreatic cancer was previously categorized into tubular, colloid, and oncocytic subtypes. Intraductal oncocytic papillary neoplasms (IOPN) has long been associated with superior prognosis/indolent behavior, however, there is discordant emerging evidence. This study aimed to investigate this conflicting literature.

methodsPatients with resected IOPN-derived and IPMN-derived pancreatic cancer were identified from six international centers. Log-rank tests compared time to (TtR) and survival after (SAR) recurrence and five-year overall survival (OS). A multivariable mixed model was used to determine hazard ratios (HR) with confidence intervals (95%CI) for five-year survival.

resultsOf 879 patients, 20 (2%) had IOPN-derived pancreatic cancer. Most patients had T1 (55%) or N0 (70%) disease. IOPN and colloid IPMN-derived pancreatic cancers had similar recurrence rates (25% vs. 24%), while recurrence was more common in tubular IPMN-derived pancreatic cancer (42%, p < 0.001). IOPN-derived pancreatic cancer displayed a longer TtR and SAR compared to colloid and tubular IPMN-derived pancreatic cancers. IOPN-derived and colloid IPMN-derived cancers demonstrated significantly lower 5-year mortality risks compared to tubular IPMN-derived cancers (74% and 27% risk reduction, respectively; p < 0.05).

conclusionIOPN-derived pancreatic cancers have excellent OS. However, some patients have poor prognostic factors and are at risk for both local and systemic recurrence. Given more indolent disease progression given delayed TtR and prolonged SAR compared to colloid and tubular IPMN-derived pancreatic cancers, there may be a role for prolonged surveillance.

Indexed as

Adenocarcinoma, MucinousCarcinoma, Pancreatic DuctalCarcinoma, PapillaryNeoplasm Recurrence, LocalPancreatic Intraductal NeoplasmsPancreatic NeoplasmsAgedAged, 80 and overFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedPrognosisRetrospective StudiesColloidIntraductal papillary mucinous neoplasmInvasive IPMNOncocyticPancreatic cancerPancreatic cystPancreatic neoplasmsTubular

Identifiers

PMID40682702

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.