Evidence map›Paper›PMID 40682688›Full record

ArticleJournal of gastrointestinal cancer2025

Prostate-Specific Membrane Antigen Expression in Colorectal Cancer and Its Potential Implication in Disease Monitoring in Rectal Cancer.

Eundong Park, Xin Wang, Michel Kmeid, Noureldien Darwish, Clifton G Fulmer, Nusret Bekir Subasi, Marcello P Toscano, Jing Zhou, Haiyan Qiu, Maciej Gracz and 2 more

Abstract read
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In one paragraph

Article in Journal of gastrointestinal cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. PSMA expression in hepatic colorectal cancer metastasis.Journal of pathology and translational medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eundong Park *Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.
Xin Wang *Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.
Michel KmeidDepartment of Pathology, Cleveland Clinic Foundation, Cleveland, OH, USA.
Noureldien DarwishPathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.
Clifton G FulmerDepartment of Pathology, Cleveland Clinic Foundation, Cleveland, OH, USA.
Nusret Bekir SubasiPathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.
Marcello P ToscanoDepartment of Pathology, Cleveland Clinic Foundation, Cleveland, OH, USA.
Jing ZhouPathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.
Haiyan QiuPathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.
Maciej GraczPathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.
Xulang ZhangPathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.
Hwajeong LeePathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA. leeh5@amc.edu.ORCID http://orcid.org/0000-0001-7005-6278

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeProstate-specific membrane antigen (PSMA) is expressed in tumor-associated vessels of diverse malignancies, such as colorectal cancer (CRC). PSMA-targeted approaches show promise for diagnosing, treating, and assessing therapy response in non-prostatic cancer. Disease monitoring following neoadjuvant chemoradiation (CRT) is especially important in rectal cancer.

methodsFirstly, clinical and histologic features of untreated CRC (n = 237; 54 from rectum) were examined for their association with PSMA expression. Secondly, rectal cancer cases following neoadjuvant CRT (n = 45) were retrieved to assess the relationship between PSMA expression, downstaging, and tumor volume reduction and were compared with untreated rectal cancers (n = 54).

resultsIn untreated CRC, PSMA expression was negatively associated with pTNM stage, pT stage, pN stage, tumor deposit presence and count, and post-op adjuvant therapy administration. Higher PSMA expression was correlated with shorter overall survival when pTNM stage was controlled. In the treated rectal cancer group, advanced pTNM stage was associated with a reduced PSMA expression. In addition, treated rectal cancers showed lower PSMA expression than untreated rectal cancers. While PSMA levels correlated with tumor volume reduction and downstaging following CRT, this association was lost in stage-matched analysis.

conclusionPSMA expression was lower in more advanced CRCs, and the trend persisted in treated rectal cancer. After adjusting for pTNM stage, higher PSMA expression was predictive of reduced overall survival. Post-CRT PSMA level was associated with downstaging and pathologic tumor volume reduction in rectal cancer. Further studies are needed to assess the clinical value of PSMA-directed approaches in CRC management.

Indexed as

Antigens, SurfaceBiomarkers, TumorColorectal NeoplasmsGlutamate Carboxypeptidase IIRectal NeoplasmsAgedChemoradiotherapy, AdjuvantFemaleHumansMaleMiddle AgedNeoadjuvant TherapyNeoplasm StagingPrognosisAntigens, SurfaceBiomarkers, TumorFOLH1 protein, humanGlutamate Carboxypeptidase IIColorectal cancerNeoadjuvant therapyProstate-specific membrane antigenRectal cancer

Identifiers

PMID40682688

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.