ArticleNeurochemical research2025
Research on the Correlation between BDNF Val76Met Polymorphism and Susceptibility to Changes of Cognitive Function in Rats Induced by Microwave Radiation.
Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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9 authors.
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Abstract
Microwave radiation is extremely sensitive to the brain and has been shown in animal models to affect memory and learning. Brain-derived neurotrophic factor (BDNF) is essential for neural function and brain development, with many single nucleotide polymorphisms (SNPs) in gene. Several neuropathological disorders have been linked to the BDNF Val66Met variation. Using CRISPR, we created BDNF Val76Met mutations in rats in this study. The rats were then subjected to X-band and S-band microwave radiation, respectively, at an average power density of 50 mW/cm² for 15 min every day for five days. We assessed cognitive capacity and investigated the neural structure and BDNF mRNA levels in the brain of rats. We discovered that BDNF Val76Met rats had impaired learning capacity and altered brain structure, with a decrease in BDNF mRNA. Meanwhile, we found that BDNF Val76Met rats exhibited aggravated structural and functional brain damage under 50mW/cm
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