Evidence map›Paper›PMID 40682669›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2025

IQGAP1 participates in bone marrow-derived macrophage recruitment and involves in liver inflammation/fibrosis.

Na Chang, Yuehan Ma, Jing Liu, Weiyang Li, Jing Zhao, Yuran Liu, Fuquan Liu, Chengbin Dong, Chang Liu, Changbo Qi and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Na Chang *Department of Cell Biology, Laboratory for Clinical Medicine, Municipal Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University, No.10 Xitoutiao You An Men, Beijing, 100069, China.
Yuehan Ma *Department of Cell Biology, Laboratory for Clinical Medicine, Municipal Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University, No.10 Xitoutiao You An Men, Beijing, 100069, China.
Jing LiuDepartment of Cell Biology, Laboratory for Clinical Medicine, Municipal Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University, No.10 Xitoutiao You An Men, Beijing, 100069, China.
Weiyang LiDepartment of Cell Biology, Laboratory for Clinical Medicine, Municipal Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University, No.10 Xitoutiao You An Men, Beijing, 100069, China.
Jing ZhaoDepartment of Cell Biology, Laboratory for Clinical Medicine, Municipal Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University, No.10 Xitoutiao You An Men, Beijing, 100069, China.
Yuran LiuDepartment of Cell Biology, Laboratory for Clinical Medicine, Municipal Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University, No.10 Xitoutiao You An Men, Beijing, 100069, China.
Fuquan LiuDepartment of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
Chengbin DongDepartment of Interventional Therapy, Beijing Shijitan Hospital, Capital Medical University, Beijing, 100038, China.
Chang LiuDepartment of Cell Biology, Laboratory for Clinical Medicine, Municipal Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University, No.10 Xitoutiao You An Men, Beijing, 100069, China.
Changbo QiDepartment of Cell Biology, Laboratory for Clinical Medicine, Municipal Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University, No.10 Xitoutiao You An Men, Beijing, 100069, China.
Lin YangDepartment of Cell Biology, Laboratory for Clinical Medicine, Municipal Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University, No.10 Xitoutiao You An Men, Beijing, 100069, China.
Liying LiDepartment of Cell Biology, Laboratory for Clinical Medicine, Municipal Laboratory for Liver Protection and Regulation of Regeneration, Capital Medical University, No.10 Xitoutiao You An Men, Beijing, 100069, China. liliying@ccmu.edu.cn.ORCID http://orcid.org/0000-0003-0470-2328

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IQ motif containing GTPase activating protein 1 (IQGAP1), a scaffold protein, is implicated in cell migration. Our previous studies demonstrate that sphingosine 1-phosphate (S1P) induces bone marrow-derived macrophages (BMDMs) recruitment and promotes chronic liver inflammation/fibrosis. However, the role of IQGAP1 in S1P-induced BMDM migration and liver inflammation/fibrosis remains unclear. Mouse liver fibrosis was induced by carbon tetrachloride (CCl

Indexed as

Liver CirrhosisMacrophagesras GTPase-Activating ProteinsAnimalsCell MovementDisease Models, AnimalHumansInflammationLiverLysophospholipidsMaleMiceMice, Inbred C57BLMicroRNAsSphingosineIQ motif containing GTPase activating protein 1LysophospholipidsMicroRNAsras GTPase-Activating ProteinsSphingosineBone marrow-derived macrophageCell migrationIQ motif containing GTPase activating protein 1Liver inflammation and fibrosisSphingosine 1-phosphate

Identifiers

PMID40682669

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.