SynthesisNeuroradiology2025
Impact of prenatal tobacco exposure on brain structure and function in offspring: a systematic review and meta-analysis of MRI findings.
Synthesis in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Earliest Impressions: A Systematic Review of Early-Life Exposures on Brain Structure and Neurodevelopmental Outcomes.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe increasing global prevalence of maternal smoking during pregnancy raises concerns about lasting effects on fetal neurological development. This review of brain magnetic resonance imaging studies aims to analyze existing literature on the influence of maternal prenatal tobacco exposure on the structure and function of the offspring's brain.
methodsA systematic search was conducted in PubMed, Web of Science, and Embase for relevant articles published before May 24, 2025. The inclusion criteria consisted of peer-reviewed original articles comparing brain magnetic resonance imaging data of offspring born to mothers with and without prenatal tobacco exposure. A coordinate-based meta-analysis using the activation likelihood estimation was also performed.
resultsOur search resulted in 471 records, with 56 articles undergoing full-text screening. Ultimately, 27 articles comparing the brain magnetic resonance imaging of 15,913 offspring, from fetus to adulthood stages, with and without prenatal tobacco exposure, were included. While the findings of the studies were heterogeneous, multiple regional and global structural (e.g., volume, cortical thickness, and surface area) and functional (task-based) alterations were identified, specifically within the frontal, temporal, and parietal regions. Also, altered white matter tract volume and diffusivity indices were repeatedly reported. Furthermore, our meta-analysis identified reduced neural activity in the right inferior frontal gyrus of tobacco-exposed offspring.
conclusionThis review highlights a considerable association between maternal smoking during pregnancy and altered offspring brain development. Further studies are essential to discern precise causal effects on the offspring's brain, development, behavior, and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.