ArticleNeuroradiology2025
Effects of hyperprolactinemia and bromocriptine treatment on cerebral blood flow and functional brain States.
Article in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Female vulnerability to microvascular transport dysfunction emerges early across the Alzheimer's disease continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
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Authors and funding
11 authors.
Funding
Abstract
purposeHyperprolactinemia (HPRL) affects both reproductive function and the central nervous system. However, its specific effects on brain function and blood flow remain unclear.
methodsThis study used multimodal magnetic resonance imaging to examine cerebral blood flow (CBF) and functional network characteristics in 32 HPRL patients, including those undergoing bromocriptine treatment, and 40 healthy controls.
resultsResults revealed a significant reduction in global mean CBF in HPRL patients, particularly in the right inferior frontal gyrus, left middle temporal gyrus, and bilateral rectus gyrus. In contrast, the right middle frontal gyrus exhibited increased CBF. Following bromocriptine treatment, global CBF showed an upward trend. Additionally, the hierarchical structure of functional networks in HPRL patients was diminished and negatively correlated with serum prolactin levels, potentially related to reduced connectivity between the default mode and sensorimotor networks.
conclusionThese findings provide new insights into how HPRL and bromocriptine influence brain function, enhancing the understanding of the underlying neurophysiological mechanisms.
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