Evidence map›Paper›PMID 40682661›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Fatigue trajectory and its associated factors in patients after pituitary adenoma surgery: a longitudinal study.

Xinyu Shen, Mu Jin, Yifan Wang, Ruiqi Zhu, Chao Wu, Chen Ma, Xin Zhao, Fang Su

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Xinyu Shen *Department of Neurosurgery, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou, 215006, China.
Mu Jin *Department of Plastic and Reconstructive Surgery, Zhongda Hospital Southeast University, Nanjing, 210009, China.
Yifan Wang *School of Nursing, Suzhou Medical College of Soochow University, Suzhou, 215006, China.
Ruiqi ZhuSchool of Nursing, Suzhou Medical College of Soochow University, Suzhou, 215006, China.
Chao WuDepartment of Neurosurgery, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou, 215006, China.
Chen MaDepartment of Neurosurgery, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou, 215006, China.
Xin ZhaoDepartment of Neurosurgery, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou, 215006, China. mumu011120@163.com.
Fang SuDepartment of Neurosurgery, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou, 215006, China. sufang1616@163.com.

Funding

Soochow University KY2023490BSuzhou Key Laboratory of Neuro-Oncology and Nano-Bionics Open Project Grant No. SZZD004
6 · The paper itself

Abstract

purposeOne of the most often reported symptoms in postoperative pituitary adenoma patients is fatigue, which frequently results in decreased mobility and activity, negatively affecting their quality of life. Identify subgroups of patients after pituitary adenoma surgery with distinct fatigue trajectories and analyze the differences in their characteristics.

methodsThis longitudinal study enrolled patients with pituitary adenoma undergoing transsphenoidal surgery. Participants completed the Identity Consequences Fatigue Scale the day before surgery (baseline/T1) and 1 day (T2), 3 days (T3), 5 days (T4), 7 days (T5), 1 month (T6), and about 3 months after surgery (T7). Identify potential categories of their fatigue trajectories based on the growth mixture model (GMM). Multivariable regression models using baseline covariates collected on the day before surgery (T1) were used to identify risk factors for incident fatigue at 3 months and to predict the resolution of fatigue. The study has been reported in accordance with the STROBE checklist.

resultsA total of 196 patients completed the baseline questionnaire, including demographics and clinical characteristics, and finally, 189 patients completed the follow-up investigation. Three potential categories of postoperative fatigue trajectories were identified in patients with pituitary adenoma: the no fatigue group (13.20%), the fatigue remission group (64.60%), and the persistent fatigue group (22.20%). Logistic regression analysis showed that engaging in high-intensity physical activity, being unemployed, having worse sleep, undergoing lumbar drainage, experiencing recurrence, and having low serum sodium concentration were the predictors of fatigue trajectory.

conclusionsThere is group heterogeneity in the trajectory of fatigue in patients with pituitary adenomas after surgery. It is recommended that healthcare providers develop individualized intervention programs based on the fatigue characteristics of postoperative patients.

Indexed as

AdenomaFatiguePituitary NeoplasmsPostoperative ComplicationsAdultAgedFemaleHumansLongitudinal StudiesMaleMiddle AgedQuality of LifeRisk FactorsSurveys and QuestionnairesLongitudinal studyPituitary adenomaPostoperative fatiguePotential categoriesPredictorsTrajectory

Identifiers

PMID40682661

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.