Evidence map›Paper›PMID 40682652›Full record

ArticleBulletin of experimental biology and medicine2025

Analysis of Lysyl Oxidase Expression and Vascular Bed in Human Uveal Melanoma.

A Yu Shatruk, N P Bgatova, N V Kononova, A V Eremina, A N Trunov, V V Chernykh, Iu S Taskaeva

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

A Yu ShatrukResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. anastasiashatruk@yandex.ru.
N P BgatovaResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
N V KononovaS. N. Fedorov National Medical Research Center "Eye Microsurgery", Ministry of Health of the Russian Federation, Novosibirsk, Russia.
A V EreminaS. N. Fedorov National Medical Research Center "Eye Microsurgery", Ministry of Health of the Russian Federation, Novosibirsk, Russia.
A N TrunovS. N. Fedorov National Medical Research Center "Eye Microsurgery", Ministry of Health of the Russian Federation, Novosibirsk, Russia.
V V ChernykhS. N. Fedorov National Medical Research Center "Eye Microsurgery", Ministry of Health of the Russian Federation, Novosibirsk, Russia.
Iu S TaskaevaResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The expression of lysyl oxidase (LOX) was assessed using immunohistochemical staining in tissue samples from the postequatorial region of the choroid and uveal melanoma obtained from human eyes enucleated for medical reasons (n = 15). It was found that LOX expression was higher in the tumor tissue. Significantly increased density of blood vessels was observed in the intratumoral region compared to the postequatorial region of the choroid. Elevated LOX expression can be associated with the formation of small blood vessels in the tumor, likely due to angiogenesis activation in human uveal melanoma.

Indexed as

MelanomaNeovascularization, PathologicProtein-Lysine 6-OxidaseUveal NeoplasmsAdultAgedChoroidFemaleHumansImmunohistochemistryMaleMiddle AgedUveal MelanomaProtein-Lysine 6-Oxidaseangiogenesislysyl oxidasetumor microenvironmentuveal melanomavascular bed

Identifiers

PMID40682652

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.