Evidence map›Paper›PMID 40682643›Full record

ArticleBulletin of experimental biology and medicine2025

The Influence of Bisphenol A on the Molecular Biological Characteristics of Human Colon Adenocarcinoma HT-29 Culture Cells.

E A Miroshnichenko, M A Diatroptova, A I Alekseeva, A D Gerasimov, A M Kosyreva

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

E A MiroshnichenkoPetrovsky National Research Center of Surgery, Avtsyn Research Institute of Human Morphology, Moscow, Russia. katerinamir10011@gmail.com.
M A DiatroptovaPetrovsky National Research Center of Surgery, Avtsyn Research Institute of Human Morphology, Moscow, Russia.
A I AlekseevaPetrovsky National Research Center of Surgery, Avtsyn Research Institute of Human Morphology, Moscow, Russia.
A D GerasimovResearch Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia Named after Patrice Lumumba (RUDN University), Moscow, Russia.
A M KosyrevaPetrovsky National Research Center of Surgery, Avtsyn Research Institute of Human Morphology, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Researchers attribute increased incidence of colorectal cancer to environmental pollution with endocrine disruptors, including the estrogen-like substance bisphenol A (BPA). The proliferative activity, viability, and mRNA expression levels of the PIK3CA, NFkBp65, VEGFA, ESR1, HIF1a, PTEN, TP53, CD44, and CDH1 genes were evaluated in human colon adenocarcinoma HT-29 cell culture incubated with different concentrations of BPA (5, 25, and 50 μM) for 24 and 96 h. Short-term (24 h) incubation with BPA did not lead to pronounced biological effects. During prolonged incubation (96 h), 5 μM BPA decreased VEGFA mRNA expression and increased HIF1a mRNA expression, 25 μM BPA increased the expression of PIK3CA, ESR1, and HIF1a mRNAs and decreased VEGFA and CD44, and 50 μM BPA increased the expression of ESR1 mRNA and was cytotoxic. Hence, the duration of incubation and the concentration of BPA in the culture medium affect the progression of the colon cancer and its malignancy.

Indexed as

AdenocarcinomaBenzhydryl CompoundsColonic NeoplasmsEndocrine DisruptorsPhenolsAntigens, CDBisphenol A CompoundsCadherinsCell ProliferationCell SurvivalClass I Phosphatidylinositol 3-KinasesEstrogen Receptor alphaGene Expression Regulation, NeoplasticHT29 CellsHumansHyaluronan ReceptorsAntigens, CDBenzhydryl Compoundsbisphenol ABisphenol A CompoundsCadherinsCD44 protein, humanCDH1 protein, humanClass I Phosphatidylinositol 3-KinasesEndocrine DisruptorsESR1 protein, humanEstrogen Receptor alphaHIF1A protein, humanHyaluronan ReceptorsHypoxia-Inducible Factor 1, alpha SubunitPhenolsPTEN PhosphohydrolasePTEN protein, humanRNA, MessengerTP53 protein, humanTumor Suppressor Protein p53Vascular Endothelial Growth Factor AVEGFA protein, humanbisphenol Acolorectal cancerendocrine disruptorsHT-29molecular mechanisms

Identifiers

PMID40682643

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.