ArticleMolecular biology reports2025
Curcumin and Silibinin loaded pegylated nanoniosome for cancer therapy: bioinformatics and in vitro study.
Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Metformin potentiates DSF/Cu-loaded pluronic nanoparticles to improve therapeutic efficacy in triple-negative breast cancer.BMC biotechnology · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTriple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that poses significant treatment challenges with conventional therapies. Innovative therapeutic approaches, including the use of phytochemicals and nanoparticles, are being explored to enhance treatment efficacy.
methodsThis study investigates the potential of PEGylated niosomes to enhance the antitumor effects of Silibinin and Curcumin against TNBC. PEGylated niosomes were synthesized using the thin-film hydration technique. Their size, Fourier-transform infrared spectroscopy (FTIR) characteristics, encapsulation efficiency, in vitro release profiles, MTT, and apoptosis testmtt were subsequently evaluated. Additionally, bioinformatics tools were used to analyze the interactions between Curcumin, Silibinin, and key proteins involved in breast cancer.
resultsThe synthesized niosomes demonstrated a consistent release pattern over 72 h, achieving a high encapsulation efficiency of 90% for Silibinin and 87% for Curcumin. The niosomes exhibited a uniform size distribution with an average diameter of 50 nm. Bioinformatics analysis using STITCH, UniProt, and Cytoscape revealed that Curcumin and Silibinin interact with critical proteins associated with breast cancer, such as EGFR, STAT3, and TP53, which influence pathways related to cell cycle regulation and apoptosis. In vitro tests on MDA-MB-231 cells indicated that dual-drug niosomes significantly reduced cell viability, induced apoptosis, and inhibited cell proliferation compared to single-drug niosomes and free drugs.
conclusionsThe findings suggest that PEGylated niosomes encapsulating Silibinin and Curcumin may serve as a promising therapeutic strategy for treating TNBC, as they target multiple cellular pathways and enhance drug delivery.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.