ArticleThe Journal of clinical endocrinology and metabolism2025
Determinants of Pancreatic Size and Fat Content in the UK Biobank: Influence of Race, Genetic Variants, and Risk Factors.
Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Intra-pancreatic fat deposition links to widespread systemic health risks: UK Biobank prospective cohort study.Insights into imaging · 2026Article
- Data-driven abdominal phenotypes of type 2 diabetes in lean, overweight, and obese cohorts from computed tomography.Journal of medical imaging (Bellingham, Wash.) · 2025Article
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
objectivePancreas size and fat content differ in individuals with diabetes, but it is not clear how pancreas imaging features are impacted by race, genetics, and lifestyle factors.
methodsWe performed cross-sectional analysis of 37 163 UK Biobank participants with pancreas imaging data to investigate racial and genetic influences on pancreas volume index (PVI) and pancreatic fat fraction (PFF). We further assessed the influence of prior glycemic status and lifestyle factors on pancreas size and composition after adjusting for sex and age.
resultsWhite nondiabetic individuals had lower PVI compared to Asian participants (P < .0001), but higher than Black participants (P < .01), whereas PFF was highest in White participants. Similar trends were observed in participants with diagnosed diabetes. When stratified by glycemic status acquired 4 to 14 years before imaging, White and Asian participants exhibited significantly lower PVI and higher PFF with increased hemoglobin A1c. Higher polygenic risk scores for type 2 diabetes and hemoglobin A1c were associated with reduced PVI (ρ = -0.07, P < .0001; and ρ = -0.14, P < .0001, respectively) and elevated PFF (ρ = 0.07, P < .0001 and ρ = 0.18, P < .0001, respectively). In contrast, type 1 diabetes polygenic risk showed no significant association with any pancreas measures. Sedentary lifestyle behaviors associated with type 2 diabetes risk at study baseline correlated with smaller PVI and increased pancreas fat 4 to 14 years later.
conclusionThese findings highlight contributions of race, genetics, and behaviors to pancreatic morphology and fat deposition in glycemic dysregulation.
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