Observational studyJournal of cosmetic dermatology2025
The Effectiveness and Safety of a Skin Care Product With Centella asiatica Leaf Extract, Ceramide NP, and Panthenol in Subjects With Sensitive Skin: A Prospective, Observational Study.
Observational study in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Care of incontinence-associated dermatitis in older adults: A randomized controlled trial comparing zinc oxide-petroleum jelly and centella asiatica-aloe vera preparations.International journal of nursing studies advances · 2026Article
- Efficacy Evaluation of N-Acyl-Phytosphingosine Prepared from Marula Oil Derived Fatty Acids in Skin Barrier Repair.Clinical, cosmetic and investigational dermatology · 2026Article
- The Effectiveness and Safety of a Skin Care Product With Centella asiatica Leaf Extract, Ceramide NP, and Panthenol in Subjects With Sensitive Skin: A Prospective, Observational Study.Journal of cosmetic dermatology · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundSensitive skin is a hyperreactive condition with rising prevalence. A holistic skin care routine is crucial for management. Selecting appropriate skin care products is of great concern in clinical practice.
aimsTo assess the effectiveness and safety of a facial cream containing Centella asiatica leaf extract, ceramide NP, and panthenol in Chinese females with sensitive skin.
methodsIn this single-center, prospective, self-controlled study, 88 female participants applied the cream on their whole face, with follow-ups at Day 2, Weeks 1, 2, and 4. The primary endpoint was the change rate of the SS-10 global score at Week 2. Non-invasive skin parameters and subject self-assessment were conducted. Adverse events (AEs) were monitored.
resultsMean SS-10 scores dropped by 66% and 76% after 2 and 4 weeks. Four symptoms (skin irritation, tautness, itching, and redness) were significantly reduced. TEWL decreased at Weeks 1 and 2, and skin pH at Week 1 and Weeks 2 and 4. SCH increased at all time points and sebum secretion at Week 4. EI, a* value, and facial red area rapidly decreased. Greater improvements were seen in the sensitive skin group compared with the slightly sensitive skin group. All AEs were mild and self-limiting.
conclusionsThis study showed the facial cream was effective and safe for 4-week use. It provided immediate relief of facial redness and discomfort, strengthened skin barrier, and modulated pH and sebum secretion, indicating favorable soothing and barrier-repairing properties for sensitive skin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.