Evidence map›Paper›PMID 40682253›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Amelogenin Null Mice Develop Osteoarthritis, While Its Application Mitigates Disease Phenotypes in a Rat Model.

Omer Helwa-Shalom, Yarden Kahlon-Suki, Shany Ivon Markowitz, Koby Goren, Dekel Shilo, Shira Schoonmaker, Chen Yochanan, Yechiel N Gellman, Shaul Beyth, Dan Deutsch and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Recombinant Human Amelogenin Protein Enhances Healing of Osteochondral Injury in a Goat Model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  3. Amelogenin Null Mice Develop Osteoarthritis, While Its Application Mitigates Disease Phenotypes in a Rat Model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Omer Helwa-ShalomThe Inter-Faculty Biotechnology Program, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID https://orcid.org/0000-0003-1538-0379
Yarden Kahlon-SukiFaculty of Dental Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID https://orcid.org/0009-0009-8917-3138
Shany Ivon MarkowitzThe Inter-Faculty Biotechnology Program, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID https://orcid.org/0000-0003-3478-3843
Koby GorenFaculty of Dental Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID https://orcid.org/0000-0001-7016-3436
Dekel ShiloFaculty of Dental Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID https://orcid.org/0000-0001-5926-9723
Shira SchoonmakerFaculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID https://orcid.org/0009-0003-1023-5065
Chen YochananFaculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID https://orcid.org/0009-0007-3358-8655
Yechiel N GellmanOrthopedic Surgery Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.ORCID https://orcid.org/0000-0003-4913-8812
Shaul BeythFaculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID https://orcid.org/0000-0002-1781-2916
Dan DeutschFaculty of Dental Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID https://orcid.org/0000-0001-5566-5665
Anat BlumenfeldFaculty of Dental Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID https://orcid.org/0000-0002-1613-050X
Hani NevoOrthopedic Surgery Department, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.ORCID https://orcid.org/0000-0002-8311-1341
Amir HazeFaculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID https://orcid.org/0000-0002-7629-3431

Funding

Israel Science Foundation (ISF) 3215/21Israel Science Foundation (ISF) 876/11
6 · The paper itself

Abstract

Previous studies have demonstrated that recombinant human amelogenin protein (rHAM

Indexed as

AmelogeninOsteoarthritisAnimalsCartilage, ArticularDisease Models, AnimalMaleMatrix Metalloproteinase 13MiceMice, Inbred C57BLMice, KnockoutPhenotypeRatsRats, Sprague-DawleyX-Ray MicrotomographyAmelogeninMatrix Metalloproteinase 13amelogeninamelogenin‐null micecartilagecollagendestabilization of medial meniscus (DMM)matrix metalloproteinase 13osteoarthritis

Identifiers

PMID40682253
PMCPMC12274640

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.