ArticlePorcine health management2025
Autogenous Streptococcus suis serotype 1 bacterin: immunogenicities of sow and gilt vaccination protocols.
Article in Porcine health management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDiseases caused by Streptococcus suis (S. suis) infection have a major impact on return on investment, use of antibiotics and animal welfare in piglet rearing worldwide. S. suis bacterins are commonly used as autogenous vaccines in different countries but experimental studies indicate limitations of bacterins in protective efficacy. In this study we read out levels of IgG, IgM and IgA binding to a S. suis serotype (cps) 1 outbreak strain and bactericidal immunity after application of a homologous bacterin to sows and gilts. In the first trial we recorded immunogenicities after preparturient sow vaccination. In the second trial we compared an intranasal versus an intramuscular second boost application in gilts, and in the third trial the impact of the second boost application prior farrowing of gilts was specifically investigated.
resultsPreparturient intramuscular application of a S. suis cps1 (sly+, mrp+, epf+) autogenous bacterin elicited significantly increased levels of serum IgG but not IgM binding to the surface of the homologous strain. Accordingly, specific serum IgG levels were significantly increased in the second and fourth week of life in piglets of these sows. Increased IgG levels were associated with decreased proliferation of S. suis cps1 in blood of 2-week-old piglets reared by vaccinated sows. The increase of IgM binding to cps1 between the fourth and sixth week of life was comparable between piglets farrowed by vaccinated and non-vaccinated sows. Levels of serum IgA binding to S. suis cps1 were not different between piglets fostered by vaccinated and non-vaccinated sows. Between the fourth and sixth week of life we recorded a significant increase in specific serum IgA levels. Intramuscular prime boost vaccination of gilts during quarantine elicited significantly increased specific serum IgG but not IgA levels. Levels of IgG in colostrum binding to S. suis cps1 were significantly increased only in gilts boostered intramuscularly 3 weeks pre farrowing and not in gilts boostered intranasally. Neither intramuscular nor intranasal boostering was associated with increased levels of specific IgA in colostrum. The significant influence of the second intramuscular boost vaccination pre farrowing in gilts on IgG levels in colostrum and in blood of 2-week-old-piglets was confirmed in the last trial.
conclusionsIntramuscular prime-boost vaccination of sows and gilts with an autogenous S. suis cps1 bacterin is associated with significantly increased levels of specific IgG in their colostrum and serum of 2- and 4-week-old piglets based on the investigations in one herd that had experienced a severe S. suis cps1 outbreak. After prime-boost vaccination during quarantine gilts should be boostered again pre-farrowing to ensure increased IgG levels in their piglets. A way to elicit increased specific IgA levels in colostrum, milk or serum through intramuscular or intranasal bacterin application was not identified.
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