Evidence map›Paper›PMID 40682172›Full record

ReviewJournal of medical case reports2025

Acquired hemophilia A: a case report and review of the literature.

Juan-Alfonso Perotti-Abad, Álvaro Cabezas-Corado, Luis Astolfi-Labrador, María Baus-Domínguez, Guillermo Machuca-Portillo, María-Ángeles Serrera-Figallo, Daniel Torres-Lagares

Abstract readCase ReportsReview
In one paragraph

Review in Journal of medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Juan-Alfonso Perotti-AbadPrivate Practice at Clínica Dental Juan Alfonso Perotti Abad, C/Doctor Marañón, 32005, Ourense, Spain.
Álvaro Cabezas-Corado *Department of Stomatology, Faculty of Dentistry, University of Seville. C/Avicena S/N, 41009, Seville, Spain.
Luis Astolfi-Labrador *Department of Stomatology, Faculty of Dentistry, University of Seville. C/Avicena S/N, 41009, Seville, Spain.
María Baus-DomínguezDepartment of Stomatology, Faculty of Dentistry, University of Seville. C/Avicena S/N, 41009, Seville, Spain. mbaus@us.es.
Guillermo Machuca-PortilloDepartment of Stomatology, Faculty of Dentistry, University of Seville. C/Avicena S/N, 41009, Seville, Spain.
María-Ángeles Serrera-FigalloDepartment of Stomatology, Faculty of Dentistry, University of Seville. C/Avicena S/N, 41009, Seville, Spain.
Daniel Torres-LagaresDepartment of Stomatology, Faculty of Dentistry, University of Seville. C/Avicena S/N, 41009, Seville, Spain. danieltl@us.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcquired hemophilia A is a rare autoimmune disease characterized by inhibitory antibodies against coagulation factor VIII, leading to an increased risk of bleeding. The relevance of this case lies in its high associated morbidity and mortality, and the importance of early diagnosis in both medical and dental practice. CASE PRESENTATION: We present the clinical case of a 74-year-old Spanish Caucasian patient diagnosed with acquired hemophilia A. The patient was initially treated for progressive edema in the right lower limb, followed by hematomas in the tongue and submandibular region. The diagnosis was confirmed through hematological tests, which revealed a prolonged activated partial thromboplastin time and low coagulation factor VIII activity (2.4%). Treatment with hemostatic agents and corticosteroids was initiated, resulting in a favorable improvement of the hematomas.

conclusionsAcquired hemophilia A requires a multidisciplinary and personalized approach for each patient. Focus should be placed on prevention, early diagnosis, and appropriate treatment to effectively manage this coagulopathy and improve patient outcomes.

Indexed as

HematomaHemophilia AAdrenal Cortex HormonesAgedFactor VIIIHemostaticsHumansMalePartial Thromboplastin TimeTreatment OutcomeAdrenal Cortex HormonesFactor VIIIHemostaticsAntibodiesaPTTCoagulation disorderDiagnosisFactor VIIIHematomaHemophilia A acquired

Identifiers

PMID40682172
PMCPMC12275370

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.