Evidence map›Paper›PMID 40682163›Full record

Trial reportCritical care (London, England)2025

Hypnosis for unplanned procedural pain in the intensive care unit: the HYPIC randomized clinical trial.

Adel Maamar, Claude Faleur, Kristell Pedrono, Marie-Pierre Adeux, Magali Anne, Adeline Verdes, Pierre Fillâtre, Matthieu Debarre, Nathalie Mercier, Matthieu Revest and 6 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04129333 (HYPIC Hypnosis for Procedural Pain in the Intensive Care Unit), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04129333 nacompletednot on this map

HYPIC Hypnosis for Procedural Pain in the Intensive Care Unit

TypeinterventionalSponsorRennes University HospitalRan2019 to 2022Enrolled80ConditionsInvasive ProcedureArmsHypnosis, No hypnosis
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Adel Maamar *Service des Médecine intensive - Réanimation, Univ Rennes, CHU Rennes, Rennes, F-35000, France. adel.maamar@chu-rennes.fr.ORCID http://orcid.org/0000-0001-8352-3613
Claude Faleur *Service des Médecine intensive - Réanimation, Univ Rennes, CHU Rennes, Rennes, F-35000, France.
Kristell PedronoService de Réanimation Polyvalente, CH Saint Brieuc, Saint Brieuc, France.
Marie-Pierre AdeuxService des Médecine intensive - Réanimation, Univ Rennes, CHU Rennes, Rennes, F-35000, France.
Magali AnneService des Médecine intensive - Réanimation, Univ Rennes, CHU Rennes, Rennes, F-35000, France.
Adeline VerdesService de Réanimation Polyvalente, CH Saint Brieuc, Saint Brieuc, France.
Pierre FillâtreService de Réanimation Polyvalente, CH Saint Brieuc, Saint Brieuc, France.
Matthieu DebarreService de Réanimation Polyvalente, CH Saint Brieuc, Saint Brieuc, France.
Nathalie MercierService de Réanimation Polyvalente, CH Saint Brieuc, Saint Brieuc, France.
Matthieu RevestService des Maladies infectieuses et réanimation médicale, Hôpital Pontchaillou, 2, rue Henri Le Guilloux, Rennes cedex 9, 35033, France.
Nicolas MassartService de Réanimation Polyvalente, CH Saint Brieuc, Saint Brieuc, France.
Noémie PoilvetService de Réanimation Polyvalente, CH Saint Brieuc, Saint Brieuc, France.
Nicolas TerziService des Médecine intensive - Réanimation, Univ Rennes, CHU Rennes, Rennes, F-35000, France.
Jean-Marc TadiéService des Médecine intensive - Réanimation, Univ Rennes, CHU Rennes, Rennes, F-35000, France.
Arnaud GacouinService des Médecine intensive - Réanimation, Univ Rennes, CHU Rennes, Rennes, F-35000, France.
Bruno LaviolleCentre d'investigation Clinique de Rennes), Service de Pharmacologie Clinique, Univ Rennes, CHU Rennes, Inserm, Rennes, 1414, F-35000, CIC, France.

Funding

Ministère des Affaires Sociales et de la Santé PHRIP-18-0299
6 · The paper itself

Abstract

backgroundPain and anxiety are frequent among critically ill patients undergoing unplanned invasive procedures, and pharmacological pain relief is not always possible. Although hypnosis is widely used in planned painful procedures, studies are lacking in this specific setting. Thus, we aimed to assess whether hypnosis plus standard care reduced pain and anxiety in critically ill patients undergoing an unplanned invasive procedure in comparison to standard care.

methodsThe HYPIC trial was a randomized, single-blind, multicenter clinical trial of hypnosis during unplanned invasive procedures versus standard care for critically ill patients conducted in two French intensive care units (ICUs) from December 27, 2019, to January 25, 2022. Patients were randomly assigned to receive hypnosis plus standard care by trained healthcare providers or standard care. The hypnotherapists were in the room for both arms to maintain blindness. The primary endpoint was the difference in pain level experienced during the invasive procedure assessed immediately after the end of the procedure between the two groups. The secondary outcomes were anxiety level, lidocaine consumption and stress experienced by the ICU nurses in charge of the patients.

resultsWe included 78 patients. The pain level, assessed with a numeric pain scale (range, 0-10), was not significantly different between the two groups (2.2 ± 2.9 vs. 2.2 ± 3, difference 0 pts [95% CI -1.3; 1.3], p = 0.89). The level of anxiety was significantly lower in the hypnosis group (2.4 ± 2.8 vs. 4.1 ± 3, difference - 1.7 [-3; -0.4], p = 0.01), as was the level of stress experienced by the ICU nurses (0.1 ± 0.4 vs. 0.9 ± 1.5, difference - 0.8 [-1.3;-0.3], p = 0.003), and the patients were three times less likely to require increased lidocaine consumption (odds ratio: 0.3 [0.13-0.84], p = 0.02) in the hypnosis group.

conclusionWhile hypnosis did not result in a statistically significant reduction in unplanned procedural pain, it seems to reduce anxiety, increase comfort, and reduce the stress level of healthcare providers.

trial registrationThe study was registered on ClinicalTrials.gov (NCT04129333) on 14 October 2019, before the first patient was enrolled.

Indexed as

HypnosisPain ManagementProcedural PainAdultAgedAnxietyFemaleFranceHumansIntensive Care UnitsMaleMiddle AgedPain MeasurementSingle-Blind MethodCatheter placementChest tubeCritical illnessHypnosisIntensive care unitRandomized controlled trial

Identifiers

PMID40682163
PMCPMC12275327

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.