ArticleEnvironmental health : a global access science source2025
Association between high polygenic risk scores and long-term exposure to air pollution in asthma development: a hospital-based case-control study.
Article in Environmental health : a global access science source, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Improving machine-learning development in allergology: bridging the gap between open-access and cohort-based databases.Current opinion in allergy and clinical immunology · 2026Review
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8 authors.
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Abstract
backgroundAir pollution is widely associated with allergic diseases, including asthma. Although previous studies have suggested an epidemiological link between air pollution and asthma, the combined effects of air pollutants and polygenic risk scores (PRSs) on asthma risk remain incompletely understood. This study aimed to examine the impact of air pollutants and PRS on asthma risk among patients in a Taiwan medical institution.
methodsThis retrospective matched case-control study utilized data from the Taiwan Precision Medicine Initiative (TPMI) project to compare asthma patients with a non-asthmatic control group. Participants were stratified into quartiles based on their asthma PRS, while air pollutant exposure was assessed by both duration and concentration. Conducted at Taichung Veterans General Hospital, the study followed participants from January 1, 2000, to December 31, 2021. Logistic regression was used to analyze the relationships between air pollution exposure, genetic risk, and asthma incidence.
resultsA total of 9,756 participants were included (3,252 asthma patients and 6,504 controls). Individuals in the highest PRS quartile demonstrated a significantly increased asthma risk (odds ratio = 1.532, 95% CI = 1.333-1.762, p < 0.0001). Long-term exposure to low levels of PM
conclusionLong-term exposure to low concentrations of air pollutants significantly increases asthma risk, especially among individuals with high genetic susceptibility. These findings emphasize the importance of personalized health management for individuals with elevated PRS.
trial registrationNot applicable.
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