Evidence map›Paper›PMID 40682141›Full record

SynthesisReproductive health2025

A global living systematic review and meta-analysis hub of emerging vaccines in pregnancy and childhood.

Agustín Ciapponi, Ariel Bardach, Mabel Berrueta, Jamile Ballivian, Martin Brizuela, Julieta Caravario, Noelia Castellana, Daniel Comande, Esteban Couto, Agustina Mazzoni and 10 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Reproductive health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Agustín CiapponiArgentine Cochrane Center, Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina. aciapponi@iecs.org.ar.
Ariel BardachCenter for Research in Epidemiology and Public Health, CONICET, Buenos Aires, Argentina.
Mabel BerruetaDepartment of Mother and Child Health, Institute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina.
Jamile BallivianInstitute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina.
Martin BrizuelaInstitute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina.
Julieta CaravarioInstitute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina.
Noelia CastellanaInstitute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina.
Daniel ComandeInstitute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina.
Esteban CoutoInstitute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina.
Agustina MazzoniInstitute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina.
Vanesa OrtegaInstitute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina.
Edward P K ParkerThe Vaccine Centre, London School of Hygiene & Tropical Medicine, London, UK.
Juan M SambadeInstitute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina.
Salva FlorenciaInstitute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina.
Juan Pablo SmutnyInstitute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina.
Katharina StegelmannInstitute for Clinical Effectiveness and Health Policy, Buenos Aires, Argentina.
Xu XiongDepartment of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
Andy StergachisUniversity of Washington Schools of Pharmacy and Public Health, Seattle, WA, USA.
Flor M MunozDepartments of Pediatrics and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Pierre BuekensDepartment of Epidemiology, Celia Scott Weatherhead School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic accelerated vaccine development and generated a rapidly evolving body of evidence before and after the vaccine rollout. We developed a robust online platform to efficiently synthesize this emerging information for current and future challenges. Expanding upon our interactive living systematic review-initially focused on COVID-19- we now include chikungunya and Lassa fever (with protocols presented in this issue), Mpox, and Disease X ( https://www.safeinpregnancy.org ). We aim to continuously monitor and periodically update and disseminate high-quality data on vaccine safety, efficacy, effectiveness, and immunogenicity in pregnancy and childhood. This platform computes real-time meta-analyses and features a visualization tool to present findings in a clear and accessible manner, supporting decision-making, vaccine development pipelines, and implementation strategies worldwide. It is also designed to integrate data on a hub of emerging vaccines in pregnancy and childhood and reflects a collaborative effort among multiple organizations.

Indexed as

COVID-19COVID-19 VaccinesChildFemaleHumansMeta-Analysis as TopicPregnancySARS-CoV-2Vaccine DevelopmentCOVID-19 Vaccines

Identifiers

PMID40682141
PMCPMC12275287

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.