ArticleBMC oral health2025
Synthesis, physical characteristics, and biocompatibility test of chitosan-alginate-fucoidan scaffold as an alternative material for alveolar bone substitution.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Path Analysis Results on Bone Markers That Influence Accelerated Bone Remodeling: An Experimental Study.Clinical and experimental dental research · 2026Article
- Fucoidan and alginate from brown seaweeds: extraction, structural diversity, biocompatibility, biodegradability, and biomedical applications.Frontiers in plant science · 2026Review
- Polymer- and Lipid-Based Nanostructures for Wound Healing with Barrier-Resolved Design.Pharmaceutics · 2025Review
- Emerging Strategies for Bioactive Agent-Loaded Xenogeneic Bone Scaffolds in Regenerative Medicine: A Comprehensive Review.Drug design, development and therapy · 2025Review
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Authors and funding
11 authors.
Funding
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Abstract
backgroundBone preservation is a critical procedure in dentistry aimed at maintaining the volume of the alveolar ridge following tooth extraction. Traditional materials used for this purpose, such as unresorbable bovine xenograft, present various drawbacks, including potential complications and limitations in biological interaction. This study explores the potential of natural materials for bone tissue engineering, specifically chitosan extracted from shrimp skin waste, alginate, and fucoidan from Sargassum species.
methodsThese materials were processed into a scaffold using the freeze-dryer method. The physical characteristics of the scaffolds were evaluated through Fourier transform-infrared spectroscopy, scanning electron microscopy, optical microscopy, and porosity tests. Biocompatibility was assessed using the haemolysis method, with scaffolds prepared at various chitosan-alginate-fucoidan ratios.
resultsThe scaffold with a chitosan-alginate-fucoidan ratio of 1.00:3.00:0.10 demonstrated significantly lower haemolysis rates and exhibited the largest pore diameter, facilitating cellular activity and nutrient exchange essential for new bone growth. This ratio also achieved the highest total porosity at a mean of 86.86 ± 0.9%.
conclusionsUtilizing natural materials in scaffold construction for bone preservation offers a promising alternative to traditional grafting methods, potentially enhancing biocompatibility and promoting effective bone regeneration in dental applications.
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