ArticleBMC urology2025
Effects of flow rate on pressure and nephrons during flexible ureteroscopy with intelligent control of renal pelvic pressure: an in-vivo pig model.
Article in BMC urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Intelligent pressure-guided flexible ureteroscopic lithotripsy improves stone-free rates and reduces infectious complications in upper urinary tract infectious stones.American journal of translational research · 2026Article
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5 authors.
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Abstract
purposeTo investigate the effects of flow rate on pressure and nephron injury during flexible ureteroscopy with intelligent renal pelvic pressure (RPP) control in an in vivo pig model.
methodsTwelve kidneys from six female pigs were randomly divided into six groups. Pressure-controlled (PC) and non-pressure-controlled (NPC) groups were continuously perfused at a flow rate of 50 mL/min (group A), 100 mL/min (group B), and 150 mL/min (group C) for 30 min. Color Doppler ultrasound detected exosmosis of the perirenal fluid. Nephron biopsies were performed in the upper, middle, and lower regions. Pressure changes and pathological conditions of the tissue at different flow rates and pressure control values were compared.
resultsRPP values for groups A, B, and C were 8.70 ± 1.02, 20.50 ± 3.03, and 45.97 ± 9.57 mmHg, respectively, and the difference was statistically significant in NPC groups (P < 0.05). RPP values with 10 mmHg control value were 9.43 ± 1.50, 9.97 ± 1.69, and 8.77 ± 1.77 mmHg, respectively. With 0 mm Hg control value, they were 0.40 ± 0.67, -0.40 ± 1.35, and 0.33 ± 1.03 mmHg, respectively, and with - 10 mmHg control value, -9.00 ± 1.34, -11.30 ± 1.15, and - 9.27 ± 1.62 mmHg, respectively. Values fluctuated around the set value, with clinically non-significant differences within 2 mmHg. Pathological examination showed that the nephron structure changed in the NPC group, with more marked changes associated with increasing flow rate. No changes were observed in the nephron morphology in the PC group regardless of perfusion flow rate.
conclusionFlexible ureteroscopy with intelligent RPP control can effectively monitor and control pressure under different perfusion flow conditions and prevent nephron injury.
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