Observational studyBMC medicine2025
Association of specific microbiota taxa in the amniotic fluid at birth with severe acute and longer-term outcomes of very preterm infants: a prospective observational study.
Observational study in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- A Potential Gut-Retina Axis in Retinopathy of Prematurity: Emerging Perspectives on Microbiome-Mediated Modulation of the IGF-1-VEGF Pathway.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundDysbiotic microbial colonization predisposes to severe outcomes of prematurity, including mortality and severe morbidities like necrotizing enterocolitis (NEC), late-onset infection (LOI) and bronchopulmonary dysplasia (BPD). Here, we studied the variations in the bacterial signatures in the amniotic fluid (AF) of very preterm deliveries < 32 weeks with severe acute and longer-term outcomes within a prospective cohort study.
methodsOne hundred twenty-six AF samples were available for 16S rRNA gene metabarcoding to describe bacterial community structure and diversity in connection to intraventricular haemorrhage (IVH), LOI, focal intestinal perforation (FIP), NEC, retinopathy of prematurity (ROP) and the 2-year cognitive (MDI) and motor (PDI) outcome.
resultsDiversity and overall bacterial community composition did not differ between the studied outcomes. But disparities in sequences assigned to single bacterial taxa were observed for the acute outcomes LOI and ROP and the longer-term impairments of MDI and PDI. Enrichments associated with a poor acute outcome were particularly detected in the Escherichia-Shigella cluster, while the predominance of Ureaplasma and Enterococcus species was associated with unrestricted acute and longer-term outcomes. Analysis for FIP did not reach any significance. IVH and NEC constituted rare events, prohibiting the analyses.
conclusionsOur data provide evidence that microbiota patterns at birth might allow the early identification of infants at risk for the severe outcomes of prematurity and argue against morbidity-specific associations. The data support the early origins hypothesis and relevant contribution of prenatal factors. The partly existing disparities between acute and longer-term outcomes might be traced back to the relevant impact of the diverse longitudinal exposures and socioeconomic factors.
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Registered trials
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