Observational studyBMC cardiovascular disorders2025
Prognostic value of carbohydrate antigen 125 combined with N-terminal pro B-type natriuretic peptide in patients with acute heart failure: a prospective cohort study in Vietnam.
Observational study in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Characterizing the molecular landscape of venous congestion.World journal of critical care medicine · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarbohydrate antigen 125 (CA125) is an emerging prognostic biomarker for acute heart failure (AHF). This study aimed to evaluate the prognostic utility of CA125 in combination with N-terminal pro-B-type natriuretic peptide (NT-proBNP) for predicting cardiovascular mortality, all-cause mortality, and a composite outcome of all-cause mortality or rehospitalization due to heart failure in patients with AHF.
methodsThis prospective observational study included 316 patients with AHF. Both CA125 and NT-proBNP levels were measured at the time of first admission. Mortality and rehospitalization due to heart failure were recorded over a 12-month follow-up period.
resultsDuring the follow-up period, 38 patients (12.0%) died from cardiovascular disease, 81 patients (25.6%) died from any cause, and 145 patients (45.9%) experienced either all-cause mortality or rehospitalization due to heart failure. In multivariate Cox regression analyses, the combination of high CA125 and high NT-proBNP levels was associated with increased risks of cardiovascular mortality (adjusted Hazard Ratio [aHR] = 11.77, 95% Confidence Interval [CI]: 3.73-37.09, p < 0.001), all-cause mortality (aHR = 4.53, 95% CI: 1.99-10.28, p < 0.001), and the composite outcome (aHR = 6.02, 95% CI: 2.75-13.24, p < 0.001). The addition of CA125 significantly improved prognostic performance when combined with NT-proBNP.
conclusionsBoth CA125 and NT-proBNP are significant prognostic biomarkers in patients with AHF. The combination of CA125 and NT-proBNP significantly enhances the prediction of cardiovascular mortality, all-cause mortality and the composite outcome of all-cause mortality or rehospitalization due to heart failure in patients with AHF.
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