ArticleBMC cancer2025
Association of triglyceride-glucose related indices with colorectal cancer risk among the US population: a cross-sectional study.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The obesity paradox effect of triglyceride-glucose-body mass index (TyG-BMI) on all-cause mortality in patients with malignant tumors: a machine learning-driven cohort study.Translational cancer research · 2026Article
- Association of preoperative insulin resistance surrogate indices with the risk of anastomotic leakage after colorectal cancer resection: a multicenter retrospective cohort.World journal of surgical oncology · 2026Article
- Association between the triglyceride-glucose index and its correlation indices and stress urinary incontinence in American adult women: a population-based cross-sectional study.Przeglad menopauzalny = Menopause review · 2026Article
- "Paradoxical" prognostic role of the TyG index and a novel machine learning-derived nomogram for colorectal cancer liver metastases.Frontiers in nutrition · 2026Article
- Comprehensive evaluation of the prevalent insulin resistance indices for pan-cancer incidence and mortality prediction.Tropical medicine and health · 2025Article
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Abstract
backgroundThe predictive value of the triglyceride-glucose (TyG)-related indices for colorectal cancer (CRC) occurrence remains unclear. This study aims to establish the association between the TyG-related index and the risk of CRC among the US population.
methodsThe TyG index, along with the Triglyceride glucose-body mass index (TyG-BMI), Triglyceride glucose-waist circumference (TyG-WC), and Triglyceride glucose-waist-to-height ratio (TyG-WHtR), were calculated using data from CRC patients in the National Health and Nutrition Examination Surveys (NHANES) spanning 1999 to 2020. Weighted multivariate logistic regression and generalized additive models assessed the independent associations between these indices and CRC risk. Subgroup analyses and sensitivity tests evaluated the robustness and reliability of the findings. Receiver operating characteristic curve (ROC) was performed for predicting CRC risk using different TyG-related indices.
resultsAmong 18,418 participants with an average age of 47.7 years, 126 were diagnosed with CRC. After adjusting for key confounding covariates, the TyG index was not significantly associated with CRC risk (OR = 1.32, 95% CI: 0.90-1.95, P = 0.1553), whereas significant positive associations remained for TyG-BMI, TyG-WC, and TyG-WtHR when analyzed as continuous variables. When categorized into quartiles, individuals in the highest quartile exhibited elevated CRC prevalence compared to the reference group (TyG: OR = 1.88, 95% CI: 0.86-4.12, P = 0.1632; TyG-BMI: OR = 2.80, 95% CI: 1.29-6.05, P = 0.0155; TyG-WC: OR = 2.71, 95% CI: 1.06-6.92, P = 0.0154; TyG-WtHR: OR = 3.62, 95% CI: 1.22-10.75, P = 0.0046), with statistically significant associations persisting for TyG-BMI, TyG-WC, and TyG-WtHR (all P < 0.05). Subgroup and interaction tests indicated that sex, age, hypertension, and diabetes did not significantly influence the association between TyG related indices and CRC risk (all P > 0.05). ROC analysis demonstrated that TyG-WtHR (AUC: 0.644, 95% CI: 0.6014-0.6917) outperformed other indices in CRC risk prediction (P < 0.001).
conclusionsIn the U.S. adult population, elevated TyG-WHtR index levels are significantly associated with a higher risk of developing CRC.
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