Evidence map›Paper›PMID 40681958›Full record

ArticleBulletin of experimental biology and medicine2025

The Effectiveness of Recombinant Human Angiogenin during Skin Burn in CD-1 Mice.

A P Lykov, A M Goryachkin, A A Prutov, M N Drovosekov, O V Poveshchenko

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

A P LykovResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. aplykov2@mail.ru.
A M GoryachkinNovosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia.
A A PrutovAngiopharm Laboratory LLC, Koltsovo, Novosibirsk region, Russia.
M N DrovosekovNovosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia.
O V PoveshchenkoResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A comparative study was conducted to investigate the effects of recombinant human angiogenin and the conditioned media of human somatic cells (bone marrow mesenchymal stromal cells, EA.Hy926 endothelial cells, and human skin fibroblasts) on burn wound healing and the levels of IL-1β, TNFα, IL-10, VEGF, and NO in blood serum and skin samples from CD-1 mice. The study found that angiogenin, similar to the conditioned media of human somatic cells, accelerated wound healing in burns. The number of cytokines in the blood serum and skin changes when angiogenin and conditioned medium of human somatic cells are applied to the burn wound site. Recombinant human angiogenin demonstrated therapeutic potential comparable to that of conditioned media from human somatic cells in terms of wound healing.

Indexed as

BurnsRibonuclease, PancreaticWound HealingAnimalsCulture Media, ConditionedEndothelial CellsFibroblastsHumansInterleukin-10Interleukin-1betaMaleMesenchymal Stem CellsMiceRecombinant ProteinsSkinTumor Necrosis Factor-alphaangiogeninCulture Media, ConditionedInterleukin-10Interleukin-1betaRecombinant ProteinsRibonuclease, PancreaticTumor Necrosis Factor-alphaVascular Endothelial Growth Factor Aburn; recombinant human angiogenin; cytokines

Identifiers

PMID40681958

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.