Evidence map›Paper›PMID 40681906›Full record

ArticleJournal of cardiovascular translational research2025

Metabolomic Profiling for Predicting Coronary Artery Aneurysms and IVIG Resistance in Kawasaki Disease- An Exploratory Study.

Zahra Amirsardari, Ehsan Aghaei Moghadam, Ali Mohebbi, Vassilios Fanos, Aryan Ayati, Michael A Portman, Fatemeh Tahghighi, Vahid Ziaee

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Article in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zahra AmirsardariSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Ehsan Aghaei MoghadamDepartment of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.
Ali MohebbiGrowth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Vassilios FanosDepartment of Surgery, University of Cagliari, Cagliari, Italy.
Aryan AyatiBakar Computational Health Sciences Institue, University of California, San Francisco, San Francisco, CA, USA.
Michael A PortmanSeattle Children's Research Institute, University of Washington, Seattle, WA, USA.
Fatemeh TahghighiDepartment of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran. f-tahghighi@sina.tums.ac.ir.
Vahid ZiaeeDepartment of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran. ziaee@tums.ac.ir.ORCID 0000-0003-4648-3573

Funding

Tehran University of Medical Sciences and Health Services 24681
6 · The paper itself

Abstract

We investigated the metabolomic profile of Kawasaki disease(KD) and its association with the development of coronary artery aneurysms (CAA) and resistance to intravenous immunoglobulin(IVIG) therapy. Metabolomic profiling was performed on 26 patients with KD. A total of 44 metabolites-including 12 amino acids, L-carnitine, and 31 acylcarnitines-were analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) after IVIG administration. Methylglutarylcarnitine, a medium-chain acylcarnitine, was identified as a differentially expressed metabolite in KD patients with CAA. Additionally, C2, C3, C14, C16, C16OH, C18:2, and C18:2OH were differentially expressed between IVIG-resistant and IVIG-responsive patients. Pathway analysis using the KEGG database revealed that arginine biosynthesis and alanine, aspartate, and glutamate metabolism were among the most affected pathways in KD patients with CAA. This study demonstrated several differentially expressed metabolites in KD patients with CAA and IVIG resistance. These findings provide new insights into the metabolic pathways underlying KD complications.

Indexed as

Coronary AneurysmDrug ResistanceImmunoglobulins, IntravenousMetabolomeMetabolomicsMucocutaneous Lymph Node SyndromeBiomarkersCarnitineCase-Control StudiesChildChild, PreschoolChromatography, LiquidFemaleHumansInfantMaleacylcarnitineBiomarkersCarnitineImmunoglobulins, IntravenousCoronary aneurysmCoronary diseaseIntravenous immunoglobulinKawasaki diseaseMetabolitesMetabolomics

Identifiers

PMID40681906

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.