ArticleNature2025
Pathology-oriented multiplexing enables integrative disease mapping.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Review
- Solute carrier membrane transporters: emerging targets in CNS disorders.Nature reviews. Drug discovery · 2026Review
- Spotlight on challenges and novel methods in highly multiplexed tissue imaging-based spatial proteomics.Journal of translational medicine · 2026Review
- Article
- Spatial and Phenotypic Heterogeneity of ILC Subsets in Mouse Lung Under Type 2 Inflammatory Conditions.European journal of immunology · 2026Article
- Infrared Near-Field Microscopy as a Platform for Nanoscale Biomedical Spectroscopy and Imaging.ACS applied materials & interfaces · 2026Review
- Generative machine learning unlocks the first proteome-wide image of human cells.bioRxiv : the preprint server for biology · 2026Article
- Photonic computing enabled end-to-end image compression and reconstruction with adjustable ratio and high-fidelity.Nature communications · 2026Article
- Dissecting Normal and Abnormal Human Kidney Development Using Multiomics.Journal of the American Society of Nephrology : JASN · 2026Review
- Continuing medical education in renal pathology: current practices and needs among nephrologists.BMC medical education · 2026Article
- Mapping multipathology via spatial omic integration.Current opinion in biotechnology · 2026Review
- Decoding cardiac homeostasis and injury: the evolving landscape of spatial transcriptomics.Frontiers in cell and developmental biology · 2026Review
- Steroid pulse therapy for acute T-cell-mediated rejection after kidney transplantation: mechanisms, evidence, and unresolved questions.Frontiers in immunology · 2026Review
- Vessel-on-a-Chip to Study Vascular Endothelial Inflammation.Current protocols · 2025Article
- Metabolite-enhanced normothermic machine perfusion improves kidney transplant viability.JCI insight · 2025Article
- Harnessing the potential of spatial statistics for spatial omics data with pasta.Nucleic acids research · 2025Article
- Adjuvant personalized cancer vaccine: is this the end of metastatic kidney cancer.Nature reviews. Urology · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
75 authors.
Malte Kuehl *Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. malte.kuehl@clin.au.dk.ORCID 0000-0003-4167-2498
Yusuke Okabayashi *III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. y_okabayashi@jikei.ac.jp.ORCID 0000-0001-7150-6947
Milagros N Wong *Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID 0009-0008-6372-7094
Lukas Gernhold *III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Gabriele Gut *Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-8991-0040
Nico KaiserInstitute of Medical Systems Bioinformatics, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0009-0006-6054-2831
Maria SchwerkIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-1185-2343
Stefanie K GräfeIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Frank Y MaDepartment of Nephrology, Monash Medical Centre and Department of Medicine, Monash University, Melbourne, Victoria, Australia.
Jovan TanevskiInstitute for Computational Biomedicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany.ORCID 0000-0001-7177-1003
Philipp S L SchäferInstitute for Computational Biomedicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany.ORCID 0009-0008-4403-8592
Sam MezherIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jacobo Sarabia Del CastilloDepartment of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-9656-1416
Thiago Goldbeck-StriederIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Olga ZolotarevaInstitute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.ORCID 0000-0002-9424-8052
Michael HartungInstitute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.ORCID 0000-0002-3992-0125
Fernando M Delgado ChavesInstitute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.
Lukas KlinkertIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Ann-Christin GnirckIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Marc SpehrDepartment of Chemosensation, Institute for Biology II, RWTH Aachen University, Aachen, Germany.ORCID 0000-0001-6616-4196
David FleckDepartment of Chemosensation, Institute for Biology II, RWTH Aachen University, Aachen, Germany.ORCID 0000-0002-6692-2388
Mehdi JoodakiInstitute for Computational Genomics, RWTH Aachen University, Aachen, Germany.
Victor ParraInstitute for Computational Genomics, RWTH Aachen University, Aachen, Germany.
Mina ShaiganInstitute for Computational Genomics, RWTH Aachen University, Aachen, Germany.
Martin DieboldFaculty of Medicine, Institute of Neuropathology, and Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.ORCID 0000-0001-9636-6936
Marco PrinzFaculty of Medicine, Institute of Neuropathology, and Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-0349-1955
Jennifer KranzDepartment of Urology and Pediatric Urology, University Hospital RWTH Aachen, Aachen, Germany.
Johan M KuxCell Communication and Migration Laboratory, Institute of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0009-0000-3734-2520
Fabian BraunIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Oliver KretzIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hui WuIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Florian GrahammerIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-7851-754X
Sven HeinsInstitute of Medical Systems Bioinformatics, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-4696-672X
Marina ZimmermannInstitute of Medical Systems Bioinformatics, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-2666-5997
Fabian HaasIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0001-5440-1035
Dominik KyliesIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nicola WannerIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jan CzogallaIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Bernhard DumoulinIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nikolay ZolotarevIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Maja LindenmeyerIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Pall KarlsonCore Center for Molecular Morphology, Section for Stereology and Microscopy, Aarhus University, Aarhus, Denmark.
Jens R NyengaardDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Marcial SebodeI. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Sören WeidemannDepartment of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
Thorsten WiechInstitute of Pathology, Nephropathology Section, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0003-4053-1474
Hermann-Josef GroeneInstitute of Pathology, Nephropathology Section, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Nicola M TomasIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-6385-9862
Catherine Meyer-SchwesingerHamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0003-1511-5188
Christoph KuppeDepartment of Nephrology, RWTH Aachen University, Medical Faculty, Aachen, Germany.ORCID 0000-0003-4597-9833
Rafael KramannDepartment of Nephrology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Alexandre KarrasDepartment of Nephrology, Georges Pompidou European Hospital, APHP, Université Paris Cité, Paris, France.
Patrick BrunevalUniversité Paris Cité, Inserm, Paris Cardiovascular Research Center (PARCC), Paris, France.ORCID 0000-0002-2350-2914
Pierre-Louis TharauxUniversité Paris Cité, Inserm, Paris Cardiovascular Research Center (PARCC), Paris, France.ORCID 0000-0002-6062-5905
Diego PasteneV. Department of Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Benito YardV. Department of Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Jennifer A SchaubDepartment of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI, USA.
Phillip J McCownDepartment of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-8012-1931
Laura PyleDepartment of Pediatrics, Division of Endocrinology and Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA.
Ye Ji ChoiDepartment of Pediatrics, Division of Endocrinology and Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA.
Takashi YokooDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.
Jan BaumbachInstitute for Computational Systems Biology, University of Hamburg, Hamburg, Germany.ORCID 0000-0002-0282-0462
Pablo J SáezCell Communication and Migration Laboratory, Institute of Biochemistry and Molecular Cell Biology, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0003-0521-9426
Ivan CostaInstitute for Computational Genomics, RWTH Aachen University, Aachen, Germany.ORCID 0000-0003-2890-8697
Jan-Eric TurnerIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-1677-5455
Jeffrey B HodginDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Julio Saez-RodriguezInstitute for Computational Biomedicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany.
Tobias B HuberIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0001-7175-5062
Petter BjornstadDepartment of Pediatrics, Division of Endocrinology and Department of Medicine, Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA, USA.
Matthias KretzlerDepartment of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-4064-0582
Olivia LenoirUniversité Paris Cité, Inserm, Paris Cardiovascular Research Center (PARCC), Paris, France.ORCID 0000-0001-8107-6987
David J Nikolic-PatersonDepartment of Nephrology, Monash Medical Centre and Department of Medicine, Monash University, Melbourne, Victoria, Australia.
Lucas PelkmansDepartment of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Stefan BonnInstitute of Medical Systems Bioinformatics, Center for Biomedical AI (bAIome), Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0003-4366-5662
Victor G PuellesDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark. v.puelles@uke.de.ORCID 0000-0002-7735-5462
Funding
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Scott Soleimanpour · 2013 to 2026
$24.3MUniversity of Michigan O'Brien Kidney Translational Core CenterP30DK081943 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PENNATHUR, SUBRAMANIAM · 2008 to 2022
$12.9MUnraveling the Impact of Per- and Polyfluoroalkyl Substances on Early Kidney Injury in Adolescents with Obesity and DiabetesR01DK129211 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Petter Bjornstad · 2021 to 2026
$3.9MPathogenesis of kidney disease in type 1 diabetes: a modern kidney biopsy cohortR01DK132399 · NIDDK · UNIVERSITY OF WASHINGTON · PI Petter Bjornstad, Ian H de Boer · 2022 to 2026
$3.0MType 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes (T1-DISCO)R01HL165433 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BJORNSTAD, PETTER, NADEAU, KRISTEN JANE · 2022 to 2025
$2.4MRenal HEIR Study: Renal Hemodynamics, Energetics and Insulin Resistance in Youth Onset Type 2 Diabetes StudyK23DK116720 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BJORNSTAD, PETTER · 2018 to 2022
$963kMeasuring metabolically active kidney tissue in autosomal dominant polycystic kidney diseaseR21DK129720 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BJORNSTAD, PETTER, GITOMER, BERENICE YOLANDE · 2021 to 2021
$242kNHLBI NIH HHS R01 HL165433NIDDK NIH HHS K23 DK116720NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK081943NIDDK NIH HHS R01 DK129211NIDDK NIH HHS R01 DK132399NIDDK NIH HHS R21 DK129720
Abstract
The expression and location of proteins in tissues represent key determinants of health and disease. Although recent advances in multiplexed imaging have expanded the number of spatially accessible proteins
Indexed as
Image Processing, Computer-AssistedAnimalsAntibodiesBiopsyDiabetic NephropathiesFemaleHumansKidneyMaleMiceProof of Concept StudySoftwareAntibodies
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.