Evidence map›Paper›PMID 40681823›Full record

ArticleScience China. Life sciences2025

Nitrate-driven maintenance of lipid homeostasis by M2 macrophages alleviates atherosclerosis via downregulation of LOX1 expression and reduction of lipid deposition.

Yuanchun Si, Haoran Du, Shaorong Li, Chunmei Zhang, Jinsong Wang, Songlin Wang, Jian Zhou

Abstract read
PubMed Publisher
In one paragraph

Article in Science China. Life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuanchun SiSalivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and School of Stomatology, Capital Medical University, Beijing, 100069, China.
Haoran DuSalivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and School of Stomatology, Capital Medical University, Beijing, 100069, China.
Shaorong LiSalivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and School of Stomatology, Capital Medical University, Beijing, 100069, China.
Chunmei ZhangSalivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and School of Stomatology, Capital Medical University, Beijing, 100069, China.
Jinsong WangSalivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and School of Stomatology, Capital Medical University, Beijing, 100069, China.
Songlin WangSalivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and School of Stomatology, Capital Medical University, Beijing, 100069, China. slwang@ccmu.edu.cn.
Jian ZhouSalivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and School of Stomatology, Capital Medical University, Beijing, 100069, China. zhoujian@ccmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis is characterized by abnormal lipid metabolism, leading to the accumulation of lipids beneath the endothelium of large arteries and the gradual formation of plaques. Unstable plaques can trigger major cardiovascular events. Although nitrate is known for its cardiovascular protective effects, such as lowering blood pressure and preventing vascular endothelial damage, its role in preventing atherosclerosis remains uncertain. This study demonstrates through animal experiments that nitrate can prevent the formation of aortic plaques induced by a high-fat diet in ApoE

Indexed as

AtherosclerosisLipid MetabolismMacrophagesNitratesScavenger Receptors, Class EAnimalsAortaApolipoproteins EApoptosisDiet, High-FatDown-RegulationFoam CellsHomeostasisMaleMiceMice, Inbred C57BLApolipoproteins ENitratesOlr1 protein, mouseScavenger Receptors, Class EatherosclerosisLox-1macrophagesnitrate

Identifiers

PMID40681823

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.