ArticleApoptosis : an international journal on programmed cell death2025
Microplastics promote chemoresistance by mediating lipid metabolism and suppressing pyroptosis in colorectal cancer.
Article in Apoptosis : an international journal on programmed cell death, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Gut microbiome remodeling induced by microplastic exposure in humans.Gut microbes · 2026Review
- The link between microplastics and colorectal cancer.Cancer metastasis reviews · 2026Review
- Micro- and nanoplastic exposure and cancer: current evidence, mechanistic pathways, and translational challenges.Translational cancer research · 2026Review
- Integration of clinical and cellular lipidomics identifies a serum metabolite signature predictive of oxaliplatin resistance in colorectal cancer.Functional & integrative genomics · 2026Article
- Tumour-infiltrating microplastics disrupt the JAK-STAT-microbiota axis to promote immunotherapy resistance in colorectal cancer.Molecular cancer · 2026Article
- Microplastic induced cascades of multiple cell death pathways: inflammation, immune imbalance, and cancer susceptibility.Frontiers in public health · 2026Review
- Microplastics' Impact on the Development of AOM/DSS-Induced Colitis-Associated Colorectal Cancer in Mice.International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Microplastics are ubiquitous environmental contaminants worldwide. Although studies have shown their potential to harm human health, the relationship between microplastics and tumors remains unclear. The intestine is the primary site for microplastics absorption, thus the impact of microplastics on colorectal cancer merits further investigation. Our results indicate that the endocytosis protein clathrin, highly expressed in cancer cells, plays a crucial role in the massive ingestion of microplastics. Further research reveals that microplastics ingestion enhances lipid absorption in colorectal cancer cells by activating the NF-κB signaling pathway. Accumulation of lipids, in turn, suppresses pyroptosis by inhibiting NLRP3/Caspase-1/GSDMD axis, thereby promoting cellular drug resistance. Moreover, microplastics accelerate colorectal cancer development in mice and enhance tumor resistance to oxaliplatin. In summary, microplastics regulate lipid metabolism and pyroptosis in colorectal cancer, emerging as a novel contributor to chemotherapy resistance in colorectal cancer against the backdrop of escalating microplastics pollution.
Indexed as
Identifiers
40681800What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.