ArticleCommunications medicine2025
High diversity of Escherichia coli causing invasive disease in neonates in Malawi poses challenges for O-antigen based vaccine approach.
Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Identification of transporter-dependent capsular loci associated with the invasive potential of Escherichia coli.Nature microbiology · 2026Article
- Temporal genomic dynamics of sequence type 39Microbial genomics · 2026Article
- Research Progress on perinatalFrontiers in microbiology · 2026Review
- Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundEscherichia coli is an important cause of neonatal sepsis and the third most prevalent cause of neonatal infection in sub-Saharan Africa, often with negative outcomes. Development of maternally administered vaccines is under consideration, but to provide adequate protection, an understanding of serotypes causing invasive disease in this population is essential. We describe the genomic characteristics of a collection of neonatal E. coli isolates from a tertiary hospital in Blantyre, Malawi, with specific reference to potential protection by vaccines under development.
methodsNeonatal blood or cerebrospinal fluid cultures from 2012 to 2021 identified 208 E. coli isolates, and 169 could be recovered for sequencing.
resultsOur data shows very high diversity in sequence types, LPS O-antigen-type and flagellar H-type, which all show temporal fluctuations and, as far as we are aware previously undescribed diversity, including ten putative novel O-types. Vaccines in clinical trials target the O-antigen but would only protect against less than half (37.9%) of neonatal sepsis cases in this population (EXPEC9V). An O-antigen-based vaccine would require 30 different O-types to protect against 80% of infections.
conclusionsVaccines against neonatal sepsis in Africa are of considerable potential value, but their development requires larger studies to establish the diversity and stability over time of relevant O-types for this population.
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Registered trials
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