Evidence map›Paper›PMID 40681754›Full record

ArticleScientific reports2025

SMARCA5 is required for the development of granule cell neuron precursors and Sonic Hedgehog Medulloblastoma growth.

Foteini Tsiami, Layla Drwesh, Surender Surender, Julia Fitzgerald, Jens Schittenhelm, David J Picketts, Rosalind A Segal, Ghazaleh Tabatabai, Daniel J Merk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Foteini TsiamiDepartment of Neurology and Interdisciplinary Neuro-Oncology, Hertie Institute for Clinical Brain Research, University Hospital Tübingen, Eberhard Karls University Tübingen, 72076, Tübingen, Germany.
Layla DrweshDepartment of Neurodegeneration, University Hospital Tübingen, Hertie Institute for Clinical Brain Research, Eberhard Karls University Tübingen, 72076, Tübingen, Germany.
Surender SurenderDepartment of Neurology and Interdisciplinary Neuro-Oncology, Hertie Institute for Clinical Brain Research, University Hospital Tübingen, Eberhard Karls University Tübingen, 72076, Tübingen, Germany.
Julia FitzgeraldDepartment of Neurodegeneration, University Hospital Tübingen, Hertie Institute for Clinical Brain Research, Eberhard Karls University Tübingen, 72076, Tübingen, Germany.
Jens SchittenhelmInstitute of Neuropathology, Department of Pathology and Neuropathology, University Hospital Tübingen, Eberhard Karls University Tübingen, 72076, Tübingen, Germany.
David J PickettsRegenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, K1H 8K6, Canada.
Rosalind A SegalDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02115, USA.
Ghazaleh TabatabaiDepartment of Neurology and Interdisciplinary Neuro-Oncology, Hertie Institute for Clinical Brain Research, University Hospital Tübingen, Eberhard Karls University Tübingen, 72076, Tübingen, Germany.
Daniel J MerkDepartment of Neurology and Interdisciplinary Neuro-Oncology, Hertie Institute for Clinical Brain Research, University Hospital Tübingen, Eberhard Karls University Tübingen, 72076, Tübingen, Germany. daniel.merk@uni-tuebingen.de.

Funding

(PQ9) The role of Bclw (bcl2l2) in preventing chemotherapy induced neuropathyR01CA205255 · NCI · DANA-FARBER CANCER INST · PI ROSALIND ANNE SEGAL · 2016 to 2026
$5.8M
NCI NIH HHS R01 CA205255
6 · The paper itself

Abstract

Medulloblastoma constitutes a molecularly diverse group of malignant embryonal brain tumors. Sonic hedgehog molecular group of medulloblastoma (SHH-MB) is a highly heterogeneous tumor entity, characterized by constitutive activation of the SHH signaling pathway. Due to lack of suitable cell line models, little is known about genetic dependencies in SHH-MB outside of the SHH pathway. By performing a CRISPR-Cas9 dropout screen in SMB21 cells derived from SHH-MB in Ptch

Indexed as

Cerebellar NeoplasmsChromosomal Proteins, Non-HistoneHedgehog ProteinsMedulloblastomaNeural Stem CellsAdenosine TriphosphatasesAnimalsCell ProliferationMiceMice, KnockoutNeuronsSignal TransductionAdenosine TriphosphatasesChromosomal Proteins, Non-HistoneHedgehog ProteinsShh protein, mouseSmarca5 protein, mouseCerebellar developmentGranule neuron precursorsSMARCA5Sonic Hedgehog Medulloblastoma

Identifiers

PMID40681754
PMCPMC12274346

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.