Observational studyEye (London, England)2025
Risk factor stratification in early-onset primary angle closure disease.
Observational study in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Accommodative Demand and Near Addition in Early-Onset Primary Angle-Closure Disease: A Comparative Study.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Distribution characteristics and influencing factors of three-dimensional lens parameters in patients with age-related cataracts.BMC ophthalmology · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo identify the potential biometric associations in patients with early-onset primary angle closure disease (EOPACD), and the relevant biometric cut-offs for distinguishing them.
designA prospective cross-sectional observational study.
participantsThe study included 190 eyes with EOPACD of 128 patients, aged 20-40 years (mean age 34.2 ± 6.0 years).
methodsEOPACD (defined as primary angle closure presenting before 40 years of age) was classified into early-onset primary angle closure suspect (EOPACS), early-onset primary angle closure (EOPAC), and early-onset primary angle closure glaucoma (EOPACG) groups. The participants underwent a baseline clinical examination, including gonioscopy, ultrasound biomicroscopy, anterior segment ocular coherent tomography (ASOCT) and optical biometry (IOL Master). Statistical analysis was performed to identify risk factors associated with EOPACG such as axial length (AL), lens thickness (LT), lens vault (LV), anterior chamber depth (ACD), anterior chamber area (ACA) and other parameters on ASOCT.
main outcome measuresTo identify ocular biometric associations and potential cut-offs for distinguishing glaucoma eyes from suspects.
resultsBiometric measurements showed that the AL was the shortest, while ACD, ACA and ASOCT angle parameters were narrowest in eyes with EOPACG, as compared to EOPACS and EOPAC (p < 0.001; Bonferroni/Dunn test). Similarly, LV and LT were highest in eyes with EOPACG (p < 0.001). Logistic regression analysis revealed that ACD exhibited the highest predictive ability (ACD ≤ 2.73 mm, OR 4.36, AUC 0.72), followed by LT (LT ≥ 4.22 mm, OR 4.2, AUC 0.71) and ACA (ACA ≤ 17.24mm
conclusionsThis study highlights the significance of ocular biometric measurements, especially ACD and LT, which can assist in stratifying individuals with EOPACD for early detection of glaucoma. Thickening of the lens with the resultant crowded anterior chamber seemed to be the most prevalent biometric characteristic in eyes with frank glaucoma.
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