Evidence map›Paper›PMID 40681723›Full record

Trial reportScientific reports2025

Implementing exercise and self-management for women with breast cancer during treatment: results of the NEXT-BRCA randomized controlled trial.

Jenna Smith-Turchyn, Derek W Stouth, Joshua A J Keogh, Elizabeth Ball, Myanca Rodrigues, Julie Richardson, Louise Bordeleau, Sarah Neil-Sztramko, Oren Levine, Lehana Thabane and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jenna Smith-TurchynSchool of Rehabilitation Science, McMaster University, 1400 Main Street W., IAHS Rm 436, Hamilton, ON, L8S 4L8, Canada. smithjf@mcmaster.ca.
Derek W StouthDepartment of Kinesiology, McMaster University, Hamilton, Canada.
Joshua A J KeoghMichael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada.
Elizabeth BallDepartment of Medical Sciences, McMaster University, Hamilton, Canada.
Myanca RodriguesHealth Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada.
Julie RichardsonSchool of Rehabilitation Science, McMaster University, 1400 Main Street W., IAHS Rm 436, Hamilton, ON, L8S 4L8, Canada.
Louise BordeleauMichael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada.
Sarah Neil-SztramkoHealth Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada.
Oren LevineMichael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada.
Lehana ThabaneHealth Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada.
Catherine M SabistonFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, Canada.
Som D MukherjeeMichael G. DeGroote School of Medicine, McMaster University, Hamilton, Canada.

Funding

Juravinski Hospital and Cancer Centre Foundation T210
6 · The paper itself

Abstract

The purpose of this study was to determine the feasibility (recruitment, retention, and adherence rates) and effectiveness of institution-based exercise and self-management (SM) on physical activity (PA) level, exercise knowledge and intention, health status, functional capacity, patient engagement, and lower extremity strength for individuals with breast cancer receiving treatment. We conducted a hybrid implementation-effectiveness trial (type 1), including female participants with a current diagnosis of breast cancer undergoing treatment. Participants were randomized to (1) exercise and SM (EXSM; 8 in person exercise sessions and SM education), (2) SM only (8 sessions of SM), or (3) usual care (UC; no intervention). The RE-AIM model was used to explore the interventions success. The primary outcome was PA level at post-intervention. An ANCOVA determined effectiveness of the intervention at each timepoint. Eighty-five participants were included in the study. Study recruitment was 72%. Both the EXSM and SM interventions had high levels of retention (EXSM: 72%; SM: 93%) and adherence (EXSM: 76%; SM: 93%). A significant effect of group was found between EXSM and UC for PA level at post-intervention timepoint (adjusted mean difference: 9.28 (95% CI 6.45, 12.10); p < 0.001), and was maintained at 6- and 12-month follow-ups (11.78 (8.93, 14.64); p < 0.001; 11.10 (8.28, 13.92); p < 0.001). Exercise and SM using strategies that maximize availability and accessibility of exercise and SM services for survivors of breast cancer can successfully be implemented during treatment within the cancer institution in Canada. Future research should explore implementation of this program at multiple centers, maximizing referral of diverse participants from diverse providers, and consider cost-effectiveness of the interventions provided over the long term in order to facilitate sustained implementation across cancer centers.

Indexed as

Breast NeoplasmsExerciseExercise TherapySelf-ManagementAdultAgedFemaleHumansMiddle AgedPatient ComplianceBreast cancerExerciseImplementation scienceRehabilitationSelf-management

Identifiers

PMID40681723
PMCPMC12274288

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.