Evidence map›Paper›PMID 40681688›Full record

ArticleArchives of toxicology2025

A hair-follicle reconstructed in vitro immunocompetent skin model for prediction of the sensitizing potential of chemicals.

Tarada Tripetchr, Marla Dubau, Sarah Hedtrich, Burkhard Kleuser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tarada TripetchrInstitute of Pharmacy, Department of Pharmacology and Toxicology, Freie Universität Berlin, Königin-Luise-Str. 2+4, 14195, Berlin, Germany.
Marla DubauInstitute of Pharmacy, Department of Pharmacology and Toxicology, Freie Universität Berlin, Königin-Luise-Str. 2+4, 14195, Berlin, Germany.
Sarah HedtrichFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada. sarah.hedtrich@ubc.ca.
Burkhard KleuserInstitute of Pharmacy, Department of Pharmacology and Toxicology, Freie Universität Berlin, Königin-Luise-Str. 2+4, 14195, Berlin, Germany. kleuser@zedat.fu-berlin.de.ORCID 0000-0002-1888-9595

Funding

Bundesministerium für Bildung und Forschung Alternatives to animal experimentsBundesministerium für Bildung und Forschung FKZ: 161L0151
6 · The paper itself

Abstract

The development of immunocompetent skin models represents a significant advancement in in vitro methods for detecting skin sensitizers, adhering to the 3R principles aimed at reducing, refining and replacing animal testing. In the present study, an advanced skin model from hair follicle-derived cells was constructed and enriched with two key immune cell types, namely Langerhans cells and T-lymphocytes, named ImmuSkin-MT. The model features a physiologically relevant epidermis and dermis, integration of monocyte-derived Langerhans cells (MoLCs) beneath the dermal layer, and co-cultivation with CD4

Indexed as

AllergensHair FollicleModels, BiologicalSkinAnimal Testing AlternativesB7-2 AntigenCD4-Positive T-LymphocytesCell ProliferationCells, CulturedCoculture TechniquesHumansLangerhans CellsAllergensB7-2 AntigenDendritic cellsFibroblastsHair folliclesKeratinocytesSkin sensitizationT-lymphocytes

Identifiers

PMID40681688
PMCPMC12454623

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.