ArticleScientific reports2025
Synthesis and swelling studies of modified chitosan smart hydrogels containing alkyl sulfonate anionic pendant groups as microparticles for insulin release.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Biofabrication ofPharmaceutics · 2026Article
- Supramolecular Effects of Alkyl Sulfonates in Silver Nanocrystal Synthesis.ACS nanoscience Au · 2026Article
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Authors and funding
5 authors.
Funding
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Abstract
The hydrogel system effectively delivered insulin, demonstrating its potential to overcome challenges associated with conventional injectable insulin therapies. This pioneering platform leverages smart hydrogels, known for their responsiveness to environmental cues such as temperature, pH, ionic strength, and concentration. Among the fabricated hydrogels, the M5 microparticle, characterized by the lowest cross-linking agent concentration (14%) and the highest propane sultone content used during its preparation, exhibited the greatest water uptake and swelling capacity. Swelling studies confirmed that hydrogel swelling behaviour is significantly influenced by both pH and temperature. Increasing pH leads to increased swelling due to electrostatic repulsion between sulfonate groups (SO
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