ArticleNature communications2025
Single-cell expression profiling of bat wing development.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Single-cell profiling decodes patagium development in gliding mammal.Nature communications · 2026Article
- Chondrocytes in fracture healing: A review of chondrocyte journey.Chinese medical journal · 2026Review
- Emerging technologies for advancing molecular and cellular research in bats.Zoological research · 2026Review
- What Factors Shape the Flyability in Bats?-The Perspective from Bat's Wing Development.Biology · 2025Review
- From Development to Regeneration: Insights into Flight Muscle Adaptations from Bat Muscle Cell Lines.Cells · 2025Article
- Single-cell expression profiling of bat wing development.Nature communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Bats are the only true-flight mammals, with wings formed by elongated digits and wing membranes. Despite the uniqueness, the cellular and molecular aspects of bat wing development remain largely unknown. Here, we use single-cell transcriptomic sequencing to map ~39,000 cells from the limbs of bats (Rhinolophus sinicus) at developmental stages Carnegie stages (CS) 16, 18, and 20. We identify 16 distinct cell populations, including a specific mesenchymal progenitor population (PDGFD+) in bat forelimbs, which may differentiate into the interdigital membrane and promote bone cell proliferation. Developing bat forelimbs exhibit prolonged chondrogenesis and delayed osteogenesis, resulting in more chondrocytes and fewer osteoblasts. The integrative analyses of data from single-cell and bulk RNA sequencing highlight the crucial roles of Notch signaling activation and WNT/β-catenin signaling suppression in bat forelimb development. Our findings provide a comprehensive single-cell atlas of developing bat limbs, offering insights into the mechanisms underlying bat wing development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.