Evidence map›Paper›PMID 40681523›Full record

ArticleNPJ microgravity2025

Feeding the cosmos: tackling personalized space nutrition and the leaky gut challenge.

B Barbero Barcenilla, R Rivero, A Lynch, W Cromer, J Gong, B Harandi, M Stegmann, H Le, D Lundine, M Chung and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ microgravity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The physiology of survival: Space.Experimental physiology · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

B Barbero BarcenillaDepartment of Biochemistry and Biophysics, Texas A&M University, College Station, TX, USA.
R RiveroDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
A LynchBioAstra, Los Angeles, CA, USA.
W CromerTexas A&M Health Science Center, Medical Physiology, Texas A&M University, College Station, TX, USA.
J GongSchool of Computing, University of Wyoming, Laramie, WY, USA.
B HarandiBioAstra, Los Angeles, CA, USA.
M StegmannBioAstra, Los Angeles, CA, USA.
H LeBioAstra, Los Angeles, CA, USA.
D LundineBioAstra, Los Angeles, CA, USA.
M ChungBioAstra, Los Angeles, CA, USA.
J PuigBioAstra, Los Angeles, CA, USA.
K MikhailovaCornell University, Ithaca, NY, USA.
H CokerDepartment of Soil and Crop Sciences, Texas A&M University, College Station, TX, USA.
A MarksPurdue University, West Lafayette, IN, USA.
R GilbertSeabrook Solutions, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
R ScottAmentum, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.
R BarkerAgricultural and biological engineering department, Purdue University, West Lafayette, IN, USA.
P GloweBioAstra, Los Angeles, CA, USA.
Eliah G OverbeyBioAstra, Los Angeles, CA, USA.
C E MasonBioAstra, Los Angeles, CA, USA. chm2042@med.cornell.edu.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Long-duration space missions pose serious challenges to astronaut nutrition and health due to the altered environment of Low Earth Orbit (LEO). This study examines the nutritional composition of crops grown in space, identifying deficiencies in key nutrients such as calcium and magnesium, along with variable antioxidant profiles. These imbalances may impact astronaut physiology, particularly bone health and immune function, and are potentially linked to altered gene expression pathways in microgravity. Emerging evidence also suggests increased intestinal permeability, referred as leaky gut syndrome, which further disrupts nutrient absorption and immune regulation. To mitigate these issues, we evaluate targeted strategies including bioengineering of nutrient-dense crops, incorporation of antioxidant-rich species, and personalized nutrition guided by pharmacogenomics. Approaches such as biofortification and tailored supplementation are proposed to address these challenges. This work contributes to the development of resilient space agriculture systems that support astronaut health during deep space missions and future planetary habitation.

Identifiers

PMID40681523
PMCPMC12274595

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.