ArticleNature communications2025
Cobalt catalyst with exclusive metal-centered chirality for asymmetric photocatalysis.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Metal-Centered Photoredox Catalysis using d6 Transition Metal-based Chromophores.Accounts of chemical research · 2026Article
- Spin-controlled enantioselective near-infrared photocatalysis with chiral MgO/CoNature communications · 2026Article
- Control over stereogenic centres beyond tetracoordination.Chemical science · 2026Review
- Stereogenic-at-Metal Ir(III) Complexes as Platforms for the Construction of Asymmetric Bimetallic Complexes.Inorganic chemistry · 2025Article
- Spin-State and Reorganization Energy Considerations for Metal-Centered Photoredox Catalysis.Journal of the American Chemical Society · 2025Article
- Bis-Homoleptic Metal Complexes of a Tridentate Ligand with a Central Anionic Sulfonamide Donor.Molecules (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
For decades, progress in chiral transition metal catalysis has been closely linked to the design of tailor-made chiral ligands. Recently, an alternative to this conventional paradigm has emerged in which the overall chirality of the catalysts arises solely from a stereogenic metal center. However, the development of such chiral-at-metal catalysts based on earth-abundant metals is still a formidable challenge. Here, we report a reactive chiral-at-cobalt catalyst comprised entirely of achiral ligands, more than a century after Alfred Werner first introduced chiral cobalt complexes with exclusive metal-centered chirality. The cobalt center uniquely serves multiple functions: it is the sole stereocenter, redox center, catalytic site, and a chromophore. While the cobalt(III) complex is inert and bench-stable under ambient conditions, it can be photoactivated through an unexpected counterion-assisted mechanism, reducing inert cobalt(III) to catalytically active cobalt(II). This chiral-at-cobalt complex enables the visible-light-activated enantioselective conversion of isoxazoles into chiral 2H-azirines, achieving high enantiomeric excess of up to 97%.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.