Evidence map›Paper›PMID 40681513›Full record

ArticleNature communications2025

Multi-component reactions via copper(I) difluorocarbene as carbonyl source for constructing α-aminoamide derivatives.

Jiuling Li, Baofan Wang, Taichen Liu, Qinghong Wen, Tongfei Jing, Xiang Fu, Yingming Pan, Kai Wei, Xiaoyu Zhou, Wenhao Hu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jiuling Li *School of Medical Sciences, Pingdingshan University, Pingdingshan, China. orgchem90@163.com.ORCID http://orcid.org/0000-0002-8619-244X
Baofan Wang *Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China.
Taichen Liu *School of Medical Sciences, Pingdingshan University, Pingdingshan, China.
Qinghong WenZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China.
Tongfei JingZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China.
Xiang FuSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Yingming PanSchool of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, China.ORCID http://orcid.org/0000-0002-3625-7647
Kai WeiSchool of Medical Sciences, Pingdingshan University, Pingdingshan, China.
Xiaoyu ZhouSchool of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou, China. zhouxiaoyu@tzc.edu.cn.ORCID http://orcid.org/0000-0002-3552-3595
Wenhao HuSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.ORCID http://orcid.org/0000-0003-1511-2614
Zhenghui KangZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan, China. kangzhenghui@simm.ac.cn.ORCID http://orcid.org/0000-0002-7489-1200

Funding

Natural Science Foundation of Henan Province (Henan Province Natural Science Foundation) 242300420201
6 · The paper itself

Abstract

Difluorocarbene, an important reactive intermediate in organic synthesis, exhibits intriguing properties and synthetic versatility. However, great challenges in modulating reaction pathways limit its widespread application in synthetic chemistry. While metal-catalyzed difluorocarbene transfer offers a promising strategy but remains a formidable challenge. Herein, we disclose a copper-mediated multicomponent reaction of amine, aldehyde and BrCF

Identifiers

PMID40681513
PMCPMC12274583

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.