Evidence map›Paper›PMID 40681451›Full record

ReviewTrends in parasitology2025

Leveraging microbial ecology for mosquito-borne disease control.

Holly L Nichols, Kerri L Coon

Abstract readReview
In one paragraph

Review in Trends in parasitology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Holly L NicholsDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, 53706, USA; Microbiology Doctoral Training Program, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Kerri L CoonDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, 53706, USA. Electronic address: kerri.coon@wisc.edu.

Funding

Toward field-ready paratransgenesis for malaria: bacterial strain optimization and microbiota interactionsU01AI184909 · NIAID · DUQUESNE UNIVERSITY · PI Kerri Lynn Coon, DAVID J LAMPE · 2025 to 2026
$1.2M
NIAID NIH HHS U01 AI184909
6 · The paper itself

Abstract

Mosquitoes transmit pathogens causing 700 000 deaths annually. Microbe-based vector control, which reduces vector populations or blocks pathogen development within vectors, offers an innovative way to lower global morbidity and mortality due to vector-borne disease. This review addresses challenges hindering the widespread adoption of microbe-based vector control in mosquitoes. We consider understudied transmission routes of mosquito-associated microbiota, factors affecting colonization and persistence of candidate microbial control agents in mosquito hosts, and the need for robust tools and methodologies to validate that observations in laboratory populations can be reliably extended to field populations. We highlight how understanding the microbial ecology underlying interactions between mosquitoes and their native microbiota can guide successful vector control efforts in these and other arthropod disease vectors.

Indexed as

CulicidaeMicrobiotaMosquito ControlMosquito VectorsVector Borne DiseasesAnimalsHumansMosquito-Borne Diseasescolonization resistancehorizontal transmissionmicrobiota transplantationparatransgenesisvertical transmission

Identifiers

PMID40681451
PMCPMC12320179

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.