Evidence map›Paper›PMID 40681349›Full record

ArticleAging and disease2025

GABA Levels Are Significantly Reduced in the Visual, Motor, and Auditory Cortex of Patients with Mild Cognitive Impairment.

Mark D Zuppichini, Abbey M Hamlin, Quan Zhou, Esther Kim, Kayla Wyatt, Noah Reardon, Benjamin M Hampstead, Thad A Polk

Abstract read
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In one paragraph

Article in Aging and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mark D ZuppichiniDepartment of Psychology, Montclair State University, Montclair, NJ, USA.
Abbey M HamlinDepartment of Psychology, The University of Texas at Austin, Austin, TX, USA.
Quan ZhouDepartments of Psychology, University of Michigan, Ann Arbor, MI, USA.
Esther KimDepartments of Psychology, University of Michigan, Ann Arbor, MI, USA.
Kayla WyattDepartments of Psychology, University of Michigan, Ann Arbor, MI, USA.
Noah ReardonDepartments of Psychology, University of Michigan, Ann Arbor, MI, USA.
Benjamin M HampsteadDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
Thad A PolkDepartments of Psychology, University of Michigan, Ann Arbor, MI, USA.

Funding

Investigating age-related neural dedifferentiation longitudinally and in Alzheimer’s pathologyR01AG050523 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI POLK, THAD A · 2016 to 2025
$5.7M
NIA NIH HHS R01 AG050523
6 · The paper itself

Abstract

One factor that might contribute to functional deterioration in patients with mild cognitive impairment (pwMCI) is a reduction in the brain's major inhibitory neurotransmitter, gamma-aminobutyric acid (GABA). Previous studies have reported reductions in GABA in pwMCI while others have not. Here we use magnetic resonance spectroscopy (MRS) to estimate GABA + macromolecules due to co-editing (GABA+) levels in six different brain regions in 37 pwMCI and 163 healthy controls. We estimate GABA+ levels using both creatine and water as reference molecules, and we analyze the effect of correcting for grey matter volume. When referenced to water, we found that GABA+ was significantly lower in pwMCI compared to controls in all six regions, even after tissue composition correction. When referenced to creatine, all but two regions exhibited lower amounts of GABA+ for pwMCI, even after controlling for tissue composition. Results suggest that pwMCI experience reductions in GABA+ throughout the brain, even in regions not typically associated with cognitive impairment.

Indexed as

Auditory CortexCognitive Dysfunctiongamma-Aminobutyric AcidMotor CortexVisual CortexAgedCase-Control StudiesFemaleHumansMagnetic Resonance SpectroscopyMaleMiddle Agedgamma-Aminobutyric Acid

Identifiers

PMID40681349
PMCPMC13256622

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.