Evidence map›Paper›PMID 40681274›Full record

ArticleJACC. Case reports2025

A Rare Case of Fulminant Myocarditis Leading to the Diagnosis of Systemic Lupus Erythematosus.

Aliya Hutman-Zahler, Jake Goldstein, Thomas Anderson, Michael Balatico, Daniel Ryan Brophy, Joni Aoki, Karla Miller, Kadie Kovach, Alan Jacobsen, Spencer Carter

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aliya Hutman-ZahlerDivision of Cardiology, Department of Medicine, University of Utah, Salt Lake City, Utah, USA. Electronic address: Aliya.hutman-zahler@hsc.utah.edu.
Jake GoldsteinDivision of Cardiology, Department of Medicine, University of Utah, Salt Lake City, Utah, USA.
Thomas AndersonDivision of Cardiology, Department of Medicine, University of Utah, Salt Lake City, Utah, USA.
Michael BalaticoDivision of Cytopathology, Department of Anatomic and Clinical Pathology, University of Utah, Salt Lake City, Utah, USA.
Daniel Ryan BrophyDivision of Cardiology, Department of Medicine, University of Utah, Salt Lake City, Utah, USA.
Joni AokiDivision of Cardiology, Department of Medicine, University of Utah, Salt Lake City, Utah, USA.
Karla MillerDivision of Rheumatology, Department of Medicine, University of Utah, Salt Lake City, Utah, USA.
Kadie KovachDivision of Cardiology, Department of Medicine, University of Utah, Salt Lake City, Utah, USA.
Alan JacobsenDivision of Cardiology, Department of Medicine, University of Utah, Salt Lake City, Utah, USA.
Spencer CarterDivision of Cardiology, Department of Medicine, University of Utah, Salt Lake City, Utah, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSystemic lupus erythematosus (SLE) is a systemic autoimmune disease with diverse manifestations, including rare occurrences of lupus myocarditis. Clinically significant lupus myocarditis as an early presentation of SLE is exceedingly uncommon. CASE SUMMARY: We present the case of a 20-year-old man with chest pain, altered mental status, and nonspecific constitutional symptoms. Investigations revealed elevated cardiac biomarkers, ST-segment elevation on electrocardiography, and reduced biventricular systolic function on echocardiography. Cardiac magnetic resonance showed abnormal parametric mapping consistent with myocarditis, confirmed on endomyocardial biopsy. Autoimmune work-up found high antinuclear antibody and double-stranded DNA titers, meeting SLE diagnostic criteria. He was treated with high-dose steroids and intravenous immunoglobulin with eventual improvement in cardiac function. DISCUSSION: This case presents a unique scenario in which myocarditis was one of the only presenting manifestations of SLE. TAKE-HOME MESSAGE: A multidisciplinary approach is critical for effective diagnosis and management.

Indexed as

acute heart failureautoimmunecardiac magnetic resonancecardiac rehabilitationright-sided catheterization

Identifiers

PMID40681274
PMCPMC12441452

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.