Evidence map›Paper›PMID 40681247›Full record

ArticleJACC. Case reports2025

Flail Tricuspid and Mitral Valve in Neonatal Lupus.

Michael N Gritti, Surabhi Sivaratnam, Osami Honjo, David Barron, Roxanne Kirsch, David Chiasson, Ronald M Laxer, Lindsay Freud

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael N GrittiDivision of Cardiology, Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: michael.gritti@sickkids.ca.
Surabhi SivaratnamDepartment of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.
Osami HonjoDivision of Cardiovascular Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada.
David BarronDivision of Cardiovascular Surgery, The Hospital for Sick Children, Toronto, Ontario, Canada.
Roxanne KirschDepartment of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada; Division of Cardiac Critical Care Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
David ChiassonDivision of Pathology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Ronald M LaxerDivision of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Lindsay FreudDivision of Cardiology, Labatt Family Heart Centre, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Pediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeonatal lupus erythematosus (NLE) typically presents as congenital heart block; flail atrioventricular valve leaflets is especially rare. CASE SUMMARY: A neonate with flail tricuspid and mitral valve resulted in severe atrioventricular valve insufficiency. There were high anti-Ro60 antibody titers consistent with NLE. Steroids and immunoglobulins were administered. Mitral and tricuspid valve repairs were undertaken. An inability to wean from extracorporeal membrane oxygenation led to the mitral valve being replaced with a modified Melody valve and then mechanical mitral valve. DISCUSSION: This is the first reported case of NLE presenting with bilateral atrioventricular valve chordal rupture, necessitating early valve replacement. This highlights a severe manifestation of NLE and has implications for diagnosis, surveillance, and novel management strategies. TAKE-HOME MESSAGES: NLE can present with atypical, life-threatening valvular pathology of both the tricuspid and mitral valve. The Melody valve offers a promising bridge to a definitive valve replacement in the mitral position.

Indexed as

cardiovascular surgerychordal rupturecongenital heart diseaseflail leafletmitral regurgitationneonatal lupus erythematosustricuspid regurgitation

Identifiers

PMID40681247
PMCPMC12441339

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.