Evidence map›Paper›PMID 40681246›Full record

ArticleJACC. Case reports2025

Ruptured Sinus of Valsalva Aneurysm With Aorto-Atrial Fistula Mimicking Tricuspid Valve Endocarditis.

Mohammed El-Nayir, Karldon Nwaezeapu, Emmanuel Daniel, Rosario Lopez-Madrid, Claudia Villarreal Carrillo, Misha Khan, Hesham Abdalla, Julia Akaah, Daniel Perry, Robert Lyons

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Enhanced surgical management of complex anal fistulasWorld journal of gastrointestinal surgery · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohammed El-NayirDepartment of Internal Medicine, Trinity Health Ann Arbor, Ypsilanti, Michigan, USA.
Karldon NwaezeapuDepartment of Internal Medicine, Trinity Health Ann Arbor, Ypsilanti, Michigan, USA.
Emmanuel DanielDepartment of Internal Medicine, Trinity Health Ann Arbor, Ypsilanti, Michigan, USA. Electronic address: Emmanuel.daniel@trinity-health.org.
Rosario Lopez-MadridDepartment of Internal Medicine, Trinity Health Ann Arbor, Ypsilanti, Michigan, USA.
Claudia Villarreal CarrilloDepartment of Internal Medicine, Trinity Health Ann Arbor, Ypsilanti, Michigan, USA.
Misha KhanDepartment of Internal Medicine, Trinity Health Ann Arbor, Ypsilanti, Michigan, USA.
Hesham AbdallaDepartment of Internal Medicine, Mayo Clinic, Scottsdale, Arizona, USA.
Julia AkaahDepartment of Internal Medicine, Trinity Health Ann Arbor, Ypsilanti, Michigan, USA.
Daniel PerryDivision of Cardiology, Trinity Health Ann Arbor, Ypsilanti, Michigan, USA.
Robert LyonsDivision of Cardiothoracic Surgery, Trinity Health Ann Arbor, Ypsilanti, Michigan, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSinus of Valsalva aneurysm (SOVA) is a rare cardiac anomaly that can lead to acute cardiovascular collapse if ruptured. Prompt diagnosis and surgical repair are vital for survival. CASE SUMMARY: A 26-year-old woman presented with right upper quadrant pain and nausea. Work-up revealed elevated inflammatory markers, congestive hepatopathy, severe aortic regurgitation, and a suspected tricuspid valve vegetation. Infectious studies were negative. Transesophageal echocardiography ultimately identified a ruptured SOVA with an aorto-right atrial fistula. She underwent successful surgical repair and made a full recovery. DISCUSSION: Ruptured SOVA can mimic infective endocarditis and may be misdiagnosed without careful imaging. In this case, what was thought to be a vegetation was a ruptured aneurysm. Multimodality imaging played a key role in diagnosis, and early surgical repair was crucial. TAKE-HOME MESSAGES: Ruptured SOVA should be suspected in young patients with right heart failure and inconclusive infectious work-up. Early diagnosis ensures optimal outcomes.

Indexed as

aortapulmonary hypertensiontricuspid valve

Identifiers

PMID40681246
PMCPMC12441427

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.