ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2025
Per- and polyfluoroalkyl substances (PFAS) toxicity and mitigation of adipogenic dysregulation in 3T3-L1 preadipocytes.
Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- A Network Toxicology Framework for Identification of Immune System Disruption by Per- and Polyfluoroalkyl Substance (PFAS) Mixture: In Silico Analysis.Journal of xenobiotics · 2026Article
- Editorial: Environmental toxicity in metabolism.Frontiers in toxicology · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Obesity and metabolic disorders are rising global concerns, with one factor linked to per- and polyfluoroalkyl substances (PFAS), a class of persistent endocrine-disrupting chemicals that affect adipogenic pathways. While PFAS are known to promote terminal lipid accumulation in mature adipocytes, their effects during dynamic adipocyte differentiation, particularly at human-relevant doses and in mixtures, remain poorly understood. This study employed 3T3-L1 preadipocytes to assess PFAS toxicity and mitigation in cell viability, redox balance, mitochondrial integrity, lipid content, and gene expression during differentiation. Repeated, low-dose exposure to 0.1 μM PFAS (individual and mixture) time-dependently reduced cell viability through induced reactive oxygen and nitrogen species by 22-49 % and reduced mitochondrial membrane potential. The 2-4-fold increase in lipid accumulation, especially by PFOA, correlated with Pparγ activation by 47-86 % (r
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