Evidence map›Paper›PMID 40681078›Full record

ArticleEnvironmental pollution (Barking, Essex : 1987)2025

Air pollution decreases postsynaptic PSD-95 and NMDA receptor subunits in synaptosomes from mouse cerebral cortex.

Jose A Godoy-Lugo, Daniel Hicks, Salma Durra, Emma R Massey, Kristina Shkirkova, Ariel I Sauri, Elizabeth Kerstiens, Selena Chen, Lifu Zhao, Constantinos Sioutas and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental pollution (Barking, Essex : 1987), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Gut Microbiota-Derived Short-Chain Fatty Acids Driven by N-Carbamylglutamate Alleviates Premature Ovarian Failure Through Suppressing Ferroptosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jose A Godoy-LugoLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Daniel HicksLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Salma DurraLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Emma R MasseyLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA; Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA, USA.
Kristina ShkirkovaKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ariel I SauriLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Elizabeth KerstiensLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Selena ChenKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lifu ZhaoKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Constantinos SioutasViterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
William J MackKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Caleb E FinchLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA; Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA, USA.
Max A ThorwaldLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. Electronic address: thorwald@usc.edu.

Funding

VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHUI, HELENA CHANG · 1985 to 2019
$41.0M
Urban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MACK, WILLIAM J · 2018 to 2022
$11.5M
Amyloid and inflammation: modulation by apoE, gender, air pollution, and drugsRF1AG051521 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FINCH, CALEB E · 2015 to 2015
$3.0M
NIA NIH HHS P01 AG055367NIA NIH HHS P50 AG005142NIA NIH HHS RF1 AG051521
6 · The paper itself

Abstract

Air pollution (AirP) increases the risk of accelerated cognitive decline, dementia, and behavioral disorders associated with oxidative damage in humans. These AirP responses are shared with rodent models. The underlying impact of AirP-mediated molecular changes on synapses remains unexplored. We examined synaptosomes extracted from cerebral cortex of mice chronically exposed to inhaled diesel exhaust particles (DEP) for 8 weeks. DEP selectively decreased postsynaptic proteins (PSD-95; p = 0.04, SAP97; p = 0.01) by at least 20 % and NMDA receptor subunits (GluN1; p = 0.03, N2A; p = 0.009, N2B; p = 0.01) by 15 %, without altering the evaluated pre-synaptic proteins. Antioxidant enzymes for oxidized phospholipid repair (GPx4; p = 0.015), iron metabolism (HMOX1; p = 0.04), and glutathione synthesis (GCLC; p = 0.008), which participate in mitigating ferroptosis, a form of cell death present in Alzheimer's disease, increased by at least 15 %. These findings suggest subcellular responses to AirP in glutamatergic synapses. Further analyses of the impact of AirP on synapses may consider protective mechanisms by antioxidant enzymes to enhance cognitive health at all ages.

Indexed as

Air PollutantsAir PollutionCerebral CortexDisks Large Homolog 4 ProteinReceptors, N-Methyl-D-AspartateSynaptosomesAnimalsMaleMiceVehicle EmissionsAir PollutantsDisks Large Homolog 4 ProteinDlg4 protein, mouseReceptors, N-Methyl-D-AspartateVehicle EmissionsAlzheimer's diseaseDiesel exhaust particlesGPx4Lipid peroxidationSynaptic membrane

Identifiers

PMID40681078
PMCPMC12288758

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.