Evidence map›Paper›PMID 40681070›Full record

ArticleEnvironmental research2025

Maternal exposure to trace elements and perfluoroalkyl acids and their associations with alterations of the hypothalamic-pituitary-adrenal axis.

Munawar Hussain Soomro, Gillian England-Mason, Gerald F Giesbrecht, Nicole Letourneau, Anthony J F Reardon, Amy M MacDonald, David W Kinniburgh, Jonathan W Martin, Deborah Dewey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Munawar Hussain SoomroDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Canada; Owerko Centre, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.
Gillian England-MasonDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Canada; Owerko Centre, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.
Gerald F GiesbrechtDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Canada; Owerko Centre, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Department of Psychology, Faculty of Arts, University of Calgary, Calgary, Alberta, Canada.
Nicole LetourneauDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Canada; Owerko Centre, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; Faculty of Nursing, University of Calgary, Calgary, Alberta, Canada; Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Anthony J F ReardonDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada.
Amy M MacDonaldAlberta Centre for Toxicology, University of Calgary, Calgary, Alberta, Canada.
David W KinniburghDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada; Alberta Centre for Toxicology, University of Calgary, Calgary, Alberta, Canada.
Jonathan W MartinScience for Life Laboratory, Department of Analytical Chemistry and Environmental Sciences, Stockholm University, Stockholm, Sweden.
Deborah DeweyDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Canada; Owerko Centre, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. Electronic address: dmdewey@ucalgary.ca.

Funding

Alberta Pregnancy Outcomes and Nutrition (APrON) - Toxicant-Diet Interactions onR21ES021295 · NIEHS · UNIVERSITY OF ALBERTA · PI MARTIN, JONATHAN WAYNE · 2012 to 2014
$320k
NIEHS NIH HHS R21 ES021295
6 · The paper itself

Abstract

Environmental exposures to trace elements and perfluoroalkyl acids (PFAAs) could alter hypothalamic-pituitary-adrenal (HPA) function during pregnancy. Concentrations of trace elements measured in maternal red blood cells and PFAAs measured in maternal plasma, as well as maternal salivary cortisol were quantified from second trimester samples in 243 women from the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort. Regression analyses examine associations between trace elements and PFAAs, and cortisol awakening response (CAR), daytime cortisol and diurnal cortisol slope. Bayesian kernel machine regression (BKMR) analyses investigated mixture effects. In single exposure models, molybdenum (β = -0.99, 95 % CI = -1.74, -0.24) was negatively associated with CAR and lead was negatively associated with daytime cortisol (β = -13.3, 95 % CI = -25.65, -1.10); perfluoroheptanoic acid (PFHpA) was positively associated (β = 4.29, 95 % CI = 0.68, 7.90) with daytime cortisol. In sex-specific analyses molybdenum was negatively associated with CAR and lead was negatively associated with daytime cortisol in women who gave birth to female infants. PFHpA and perfluorohexanesulfonic acid (PFHxS), were positively associated with daytime cortisol in women who gave birth to male infants. Arsenic, mercury, zinc, PFHxS and perfluorooctanesulfonic acid (PFOS) were positively associated with diurnal cortisol slope in the women who gave birth to female infants. No associations survived correction for false discovery rate. In mixture models, molybdenum was the main contributor to CAR in women who gave birth to female infants; PFHpA contributed the most to daytime cortisol in women who gave birth to male infants. Exposure to trace elements and PFAAs in pregnancy may be associated with alterations in maternal HPA axis function.

Indexed as

Environmental PollutantsFluorocarbonsHypothalamo-Hypophyseal SystemMaternal ExposurePituitary-Adrenal SystemTrace ElementsAdultAlbertaCohort StudiesFemaleHumansHydrocortisoneMalePregnancySalivaYoung AdultEnvironmental PollutantsFluorocarbonsHydrocortisoneTrace ElementsAPrON studyCortisolCortisol awakening responseHypothalamic-pituitary-adrenal axisPerfluoroalkyl acidsTrace elements

Identifiers

PMID40681070
PMCPMC13197170

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.